| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
DNM1L (DRP1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:8000 |
| Notes: |
Titration of the DNM1L antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This DNM1L antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O00429 |
| Purity: |
Antigen affinity |
| Description: |
Also required for mitochondrial fission during mitosis, Facilitates developmentally regulated apoptosis during neural tube formation, Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism, Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, Required for a normal rate of cytochrome c release and caspase activation during apoptosis, Required for formation of endocytic vesicles, Required for normal brain development, Required for programmed necrosis execution, Through its function in mitochondrial division, [UniProt], by suppressing oxidative damage, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, including that of cerebellum, the function may require its recruitment by MFF to clathrin-containing vesicles, this requirement may depend upon the cell type and the physiological apoptotic cues, Functions in mitochondrial and peroxisomal division |
| Immunogen: |
This DNM1L antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 513-547 amino acids from the C-terminal region of human DRP1/DNM1L |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the DNM1L antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
DNM1L (DRP1) |
| Short name: |
DNM1L Antibody (DRP1) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
dynamin 1-like (Antibody to) (DRP1) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, DLP1 and DRP1 and DVLP and DYMPLE and EMPF and HDYNIV, DNM1L and IDBG-26348 and ENSG00000087470 and 10059, DNM1L and IDBG-638362 and ENSBTAG00000011395 and 540892, Dnm1l and IDBG-136828 and ENSMUSG00000022789 and 74006, protein homodimerization activity, this GO :0000266 and mitochondrial fission and biological process this GO :0001836 and release of cytochrome c from mitochondria and biological process this GO :0003374 and dynamin polymerization involved in mitochondrial fission and biological process this GO :0003924 and GTPase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005777 and peroxisome and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005874 and microtubule and cellular component this GO :0005905 and coated pit and cellular component this GO :0006184 and GTP catabolic process and biological process this GO :0006897 and endocytosis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006921 and cellular component disassembly involved in execution phase of apoptosis and biological process this GO :0008289 and lipid binding and molecular function this GO :0010821 and regulation of mitochondrion organization and biological process this GO :0016020 and membrane and cellular component this GO :0016559 and peroxisome fission and biological process this GO :0030054 and cell junction and cellular component this GO :0030672 and synaptic vesicle membrane and cellular component this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032459 and regulation of protein oli this GO merization and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043234 and protein complex and cellular component this GO :0043653 and mitochondrial fragmentation involved in apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050714 and positive regulation of protein secretion and biological process this GO :0051289 and protein homotetramerization and biological process this GO :0061025 and membrane fusion and biological process this GO :0070266 and necroptotic process and biological process this GO :0070584 and mitochondrion morphogenesis and biological process this GO :0070585 and protein localization to mitochondrion and biological process this GO :0090141 and positive regulation of mitochondrial fission and biological process this GO :0090149 and membrane fission involved in mitochondrial fission and biological process this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process this GO :1900063 and regulation of peroxisome organization and biological process this GO :2001244 and positive regulation of intrinsic apoptotic signaling pathway and biological process, this GO :0003924 : GTPase activity, this GO :0003924 : GTPase activity and also this GO :0005515 : protein binding and also this GO :0005525 : GTP binding and also this GO :0008289 : lipid binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity, this GO :0005515 : protein binding, this GO :0005525 : GTP binding, this GO :0008289 : lipid binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, dynamin 1-like |
| Identity: |
2973 |
| Gene: |
DNM1L |
More about : DNM1L |
| Long gene name: |
dynamin 1 like |
| Synonyms: |
DRP1 DVLP HDYNIV DYMPLE VPS1 |
| Locus: |
12p11, 21 |
| Discovery year: |
2000-04-12 |
| GenBank acession: |
AF000430 |
| Entrez gene record: |
10059 |
| Pubmed identfication: |
9348079 9731200 |
| RefSeq identity: |
NM_012062 |
| Havana BLAST/BLAT: |
OTTHUMG00000169451 |