| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Fibroblast Growth Factor Receptor 3 (FGFR3) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the FGFR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This FGFR3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q61851 |
| Purity: |
Antigen affinity |
| Description: |
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, CBL and FRS2, GAB1, Ligand binding leads to the activation of several signaling cascades, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, Over-expressed or constitutively activated FGFR3 promotes activation of STAT1, PIK3R1 and SOS1, Phosphorylates PLCG1, Phosphorylation of FRS2 triggers recruitment of GRB2, Plays a role in postnatal lung development, Plays a role in the regulation of vitamin D metabolism, Plays an essential role in the regulation of chondrocyte differentiation, Promotes apoptosis in chondrocytes, Regulates both osteogenesis and postnatal bone mineralization by osteoblasts, Required for normal development of the inner ear, STAT5A and STAT5B, and is required for normal skeleton development, and mediates activation of RAS, as well as of the AKT1 signaling pathway, but can also promote cancer cell proliferation, differentiation and apoptosis, internalization and degradation lead to aberrant signaling, proliferation and apoptosis, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation |
| Immunogen: |
This FGFR3 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 449-482 amino acids from the central region of mouse Fgfr3 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the FGFR3 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Fibroblast Growth Factor Receptor 3 (FGFR3) |
| Short name: |
Fibroblast Growth Factor Receptor 3 Antibody (FGFR3) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Fibroblast Growth Factor Receptor 3 (Antibody to) (FGFR3) |
| Alternative technique: |
antibodies |
| Identity: |
3690 |
| Gene: |
FGFR3 |
More about : FGFR3 |
| Long gene name: |
fibroblast growth factor receptor 3 |
| Synonyms gene: |
ACH |
| Synonyms gene name: |
achondroplasia, thanatophoric dwarfism |
| Synonyms: |
CEK2 JTK4 CD333 |
| Locus: |
4p16, 3 |
| Discovery year: |
1991-06-07 |
| GenBank acession: |
M64347 |
| Entrez gene record: |
2261 |
| Pubmed identfication: |
1847508 |
| RefSeq identity: |
NM_000142 |
| Classification: |
I-set domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000121148 |
| Locus Specific Databases: |
LRG_1021 |