| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Fibroblast Growth Factor Receptor 3 (FGFR3) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the FGFR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This FGFR3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P22607 |
| Purity: |
Purified |
| Description: |
A full-length representative protein would consist of an extracellular region, FGFR family members differ from one another in their ligand affinities and tissue distribution, Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia, The extracellular portion of the protein interacts with fibroblast growth factors, This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain, composed of three immunoglobulin-like domains, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation, where amino acid sequence is highly conserved between members and throughout evolution, FGFR3 is a member of the fibroblast growth factor receptor family |
| Immunogen: |
A portion of amino acids 776-806 from the human protein was used as the immunogen for this FGFR3 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the FGFR3 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Fibroblast Growth Factor Receptor 3 (FGFR3) |
| Short name: |
Fibroblast Growth Factor Receptor 3 Antibody (FGFR3) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Fibroblast Growth Factor Receptor 3 (Antibody to) (FGFR3) |
| Alternative technique: |
antibodies |
| Identity: |
3690 |
| Gene: |
FGFR3 |
More about : FGFR3 |
| Long gene name: |
fibroblast growth factor receptor 3 |
| Synonyms gene: |
ACH |
| Synonyms gene name: |
achondroplasia, thanatophoric dwarfism |
| Synonyms: |
CEK2 JTK4 CD333 |
| Locus: |
4p16, 3 |
| Discovery year: |
1991-06-07 |
| GenBank acession: |
M64347 |
| Entrez gene record: |
2261 |
| Pubmed identfication: |
1847508 |
| RefSeq identity: |
NM_000142 |
| Classification: |
I-set domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000121148 |
| Locus Specific Databases: |
LRG_1021 |