| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
AANAT |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Intented use: |
This AANAT antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q16613 |
| Purity: |
Antigen affinity |
| Description: |
It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland, Melatonin is essential for the function of the circadian clock that influences activity and sleep, This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation, This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome, Serotonin N-acetyltransferase/AANAT belongs to the acetyltransferase superfamily |
| Immunogen: |
A portion of amino acids 27-54 from the human protein was used as the immunogen for this AANAT antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the AANAT antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
AANAT |
| Short name: |
AANAT Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
aralkylamine N-acetyltransferase (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
14-3-3 protein binding, AANAT and IDBG-69711 and ENSG00000129673 and 15, Aanat and IDBG-214486 and ENSMUSG00000020804 and 11298, Cytoplasm, DSPS and SNAT, this GO :0004059 and aralkylamine N-acetyltransferase activity and molecular function this GO :0004060 and arylamine N-acetyltransferase activity and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006474 and N-terminal protein amino acid acetylation and biological process this GO :0007623 and circadian rhythm and biological process this GO :0008080 and N-acetyltransferase activity and molecular function this GO :0009416 and response to light stimulus and biological process this GO :0010043 and response to zinc ion and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0030187 and melatonin biosynthetic process and biological process this GO :0032868 and response to insulin and biological process this GO :0034097 and response to cytokine and biological process this GO :0034641 and cellular nitrogen compound metabolic process and biological process this GO :0034695 and response to prostaglandin E and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0046219 and indolalkylamine biosynthetic process and biological process this GO :0046688 and response to copper ion and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051412 and response to corticosterone and biological process this GO :0051591 and response to cAMP and biological process this GO :0051592 and response to calcium ion and biological process this GO :0071320 and cellular response to cAMP and biological process this GO :0071889 and 14-3-3 protein binding and molecular function, this GO :0004059 : aralkylamine N-acetyltransferase activity, this GO :0004059 : aralkylamine N-acetyltransferase activity and also this GO :0004060 : arylamine N-acetyltransferase activity and also this GO :0008080 : N-acetyltransferase activity and also this GO :0071889 : 14-3-3 protein binding, this GO :0004060 : arylamine N-acetyltransferase activity, this GO :0008080 : N-acetyltransferase activity, this GO :0071889 : 14-3-3 protein binding, aralkylamine N-acetyltransferase |
| Identity: |
19 |
| Gene: |
AANAT |
More about : AANAT |
| Long gene name: |
aralkylamine N-acetyltransferase |
| Synonyms gene name: |
arylalkylamine N-acetyltransferase |
| Synonyms: |
SNAT |
| Synonyms name: |
serotonin N-acetyltransferase |
| Locus: |
17q25, 1 |
| Discovery year: |
1995-12-13 |
| GenBank acession: |
U40347 |
| Entrez gene record: |
15 |
| Pubmed identfication: |
8661026 |
| RefSeq identity: |
NM_001088 |
| Classification: |
GCN5 related N-acetyltransferases |
| Havana BLAST/BLAT: |
OTTHUMG00000180179 |