| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PTP1B |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the PTP1B antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This PTP1B antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P18031 |
| Purity: |
Purified |
| Description: |
Members of the PTP family share a highly conserved catalytic motif, PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues, This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase, This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, and cell response to interferon stimulation, and oncogenic transformation, as well as JAK2 and TYK2 kinases, differentiation, mitotic cycle, which implicated the role of this PTP in cell growth control, which is essential for the catalytic activity, which was isolated and identified based on its enzymatic activity and amino acid sequence, PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family |
| Immunogen: |
This PTP1B antibody was produced from rabbits immunized with a recombinant protein encoding aa 1~321 of human PTP1B |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PTP1B antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PTP1B |
| Short name: |
PTP1B Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PTP1B (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9642 |
| Gene: |
PTPN1 |
More about : PTPN1 |
| Long gene name: |
non-receptor type 1 , protein tyrosine phosphatase |
| Synonyms gene: |
PTP1B |
| Locus: |
20q13, 13 |
| Discovery year: |
1991-09-13 |
| Entrez gene record: |
5770 |
| Pubmed identfication: |
2164224 |
| Classification: |
Protein tyrosine phosphatases, non-receptor type |
| Havana BLAST/BLAT: |
OTTHUMG00000032729 |