| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ZAK (MLKLAK) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the ZAK antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This ZAK antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9NYL2 |
| Purity: |
Purified |
| Description: |
It possesses an N-terminal kinase catalytic domain, The protein also has pro-apoptotic activity, The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells, This magnesium-binding protein forms homodimers and is located in the cytoplasm, followed by a leucine zipper motif and a sterile-alpha motif (SAM), ZAK/MLKLAK is a member of the MAPKKK family of signal transduction molecules |
| Immunogen: |
A portion of amino acids 271-300 from the human protein was used as the immunogen for this ZAK antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the ZAK antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ZAK (MLKLAK) |
| Short name: |
ZAK Antibody (MLKLAK) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Mitogen-activated protein kinase kinase kinase MLT (Antibody to) (MLKLAK) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
B230120H23Rik and IDBG-179557 and ENSMUSG00000004085 and 65964, BT, ZAK and IDBG-75233 and ENSG00000091436 and 51776, nuclei, this GO :0000075 and cell cycle checkpoint and biological process this GO :0000077 and DNA damage checkpoint and biological process this GO :0000186 and activation of MAPKK activity and biological process this GO :0000287 and magnesium ion binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004709 and MAP kinase kinase kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006950 and response to stress and biological process this GO :0007010 and cytoskeleton organization and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007257 and activation of JUN kinase activity and biological process this GO :0008219 and cell death and biological process this GO :0008283 and cell proliferation and biological process this GO :0009314 and response to radiation and biological process this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004709 : MAP kinase kinase kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004709 : MAP kinase kinase kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0044822 : poly(A) RNA binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0044822 : poly(A) RNA binding, transferring phosphorus-containing groups and molecular function this GO :0030154 and cell differentiation and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0044822 and poly(A) RNA binding and molecular function, 55601 and IDBG-640550 and ENSBTAG00000001083 and 519251, Mitogen-activated protein kinase kinase kinase MLT |
| Identity: |
17797 |
| Gene: |
MAP3K20 |
More about : MAP3K20 |
| Long gene name: |
mitogen-activated protein kinase kinase kinase 20 |
| Synonyms: |
MLTKalpha MLTKbeta ZAK MLTK MLK7 MRK |
| Synonyms name: |
ZAK1 homolog, leucine zipper and sterile-alpha motif kinase (Dictyostelium) mixed lineage kinase 7 |
| Locus: |
2q31, 1 |
| Discovery year: |
2016-10-19 |
| GenBank acession: |
AB049733 |
| Entrez gene record: |
51776 |
| Pubmed identfication: |
10924358 |
| RefSeq identity: |
NM_016653 |
| Classification: |
Mitogen-activated protein kinase kinase kinases |