| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TIE2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB, IHC |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the TIE2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This TIE2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q02763 |
| Purity: |
Purified |
| Description: |
Defects in TEK are associated with inherited venous malformations, TEK is closely related to the TIE receptor tyrosine kinase, The ligand for the receptor is angiopoietin-1, This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats, and humans, rats, the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice |
| Immunogen: |
A portion of amino acids 758-789 from the human protein was used as the immunogen for this TIE2 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the TIE2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TIE2 |
| Short name: |
TIE2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TIE2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11724 |
| Gene: |
TEK |
More about : TEK |
| Long gene name: |
TEK receptor tyrosine kinase |
| Synonyms gene: |
VMCM |
| Synonyms gene name: |
endothelial , multiple cutaneous and mucosal TEK tyrosine kinase, venous malformations |
| Synonyms: |
TIE2 TIE-2 VMCM1 CD202b |
| Locus: |
9p21, 2 |
| Discovery year: |
1994-05-24 |
| GenBank acession: |
L06139 |
| Entrez gene record: |
7010 |
| Pubmed identfication: |
1312667 7833915 |
| Classification: |
Fibronectin type III domain containing CD molecules Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000019712 |