| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
MUSK |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IF, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the MUSK antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This MUSK antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O15146 |
| Purity: |
Purified |
| Description: |
It has been shown that a majority of AChR Ab-seronegative myasthenia gravis patients possess serum autoantibodies against MuSK, MuSK also mediates agrin-induced aggregation of acetylcholine receptors at the mature vertebrate neuromuscular junction and also during synapse formation, and presynaptic differentiation, including the organization of the postsynaptic membrane, synapse-specific transcription, MuSK activates signaling cascades responsible for many aspects of synapse formation |
| Immunogen: |
This MUSK antibody was produced from rabbits immunized with human MUSK recombinant protein |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the MUSK antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
MUSK |
| Short name: |
MUSK Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MUSK (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7525 |
| Gene: |
MUSK |
More about : MUSK |
| Long gene name: |
muscle associated receptor tyrosine kinase |
| Synonyms gene name: |
muscle, receptor tyrosine kinase , skeletal |
| Locus: |
9q31, 3 |
| Discovery year: |
1997-04-10 |
| GenBank acession: |
AF006464 |
| Entrez gene record: |
4593 |
| Pubmed identfication: |
7546737 |
| Classification: |
I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000020485 |