| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
FGFR2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Primate, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IF, WB, IHC |
| Recommended dilutions: |
IHC (Paraffin): 1:25, Immunofluorescence: 1:25, Western blot: 1:1000 |
| Notes: |
Titration of the FGFR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This FGFR2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P21802 |
| Purity: |
Purified |
| Description: |
A full-length representative protein consists of an extracellular region, Alternative splicing in multiple exons, FGFR family members differ from one another in their ligand affinities and tissue distribution, Isoform 1 has equal affinity for aFGF and bFGF but does not bind KGF, Mutations in the gene are associated with many craniosynostotic syndromes and bone malformations, The extracellular portion of the protein interacts with fibroblast growth factors, The genomic organization of the gene encompasses 20 exons, This particular family member is a high-affinity receptor for acidic, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain, basic and/or keratinocyte growth factor, composed of three immunoglobulin-like domains, depending on the isoform, including those encoding the Ig-like domains, results in varied isoforms which differ in structure and specificity, setting in motion a cascade of downstream signals, the transmembrane region and the carboxyl terminus, ultimately influencing mitogenesis and differentiation, where amino acid sequence is highly conserved between members and throughout evolution, FGFR2 is a member of the fibroblast growth factor receptor family |
| Immunogen: |
A portion of amino acids 7-37 from the human protein was used as the immunogen for this FGFR2 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the FGFR2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
FGFR2 |
| Short name: |
FGFR2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FGFR2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3689 |
| Gene: |
FGFR2 |
More about : FGFR2 |
| Long gene name: |
fibroblast growth factor receptor 2 |
| Synonyms gene: |
KGFR BEK CFD1 JWS |
| Synonyms gene name: |
bacteria-expressed kinase keratinocyte growth factor receptor craniofacial dysostosis 1 Jackson-Weiss syndrome |
| Synonyms: |
CEK3 TK14 TK25 ECT1 K-SAM CD332 |
| Synonyms name: |
Crouzon syndrome Pfeiffer syndrome |
| Locus: |
10q26, 13 |
| Discovery year: |
1991-05-09 |
| GenBank acession: |
AK026508 |
| Entrez gene record: |
2263 |
| RefSeq identity: |
NM_022976 NM_000141 |
| Classification: |
I-set domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000019175 |
| Locus Specific Databases: |
LRG_994 |