| Long name: |
FGFR2 Primary Polyclonal Antibody |
| Also known as: |
FGFR2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FGFR2 |
| Specificity: |
This is a highly specific antibody against FGFR2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FGFR2 |
| Gene ID number: |
2263 |
| Swiss Prot: |
P21802 |
| Tested Applications: |
IHC-P, FCM |
| Recommended dilutions: |
IHC-P(1:100-500), FCM(1:20-100) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, FGFR2 signaling is down-regulated by ubiquitination, FRS2 and PAK4, GAB1, Ligand binding leads to the activation of several signaling cascades, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, Over-expressed FGFR2 promotes activation of STAT1, PIK3R1 and SOS1, Phosphorylates PLCG1, Phosphorylation of FRS2 triggers recruitment of GRB2, Plays an essential role in the regulation of osteoblast differentiation, Promotes cell proliferation in keratinocytes and immature osteoblasts, Required for normal embryonic patterning, and in the regulation of embryonic development, and is required for normal skeleton development, and mediates activation of RAS, as well as of the AKT1 signaling pathway, but promotes apoptosis in differentiated osteoblasts, differentiation, internalization and degradation, internalization and degradation lead to aberrant signaling, limb bud development, lung morphogenesis, migration and apoptosis, osteogenesis and skin development, proliferation and apoptosis, trophoblast function, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BBDS, BFR-1, CD332, CEK3, CFD1, ECT1, FGFR-2, FGFR2, Fibroblast growth factor receptor 2, JWS, K-SAM, KGFR, KSAM, Keratinocyte growth factor receptor, TK14, TK25, BEK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FGFR2 |
| Short name: |
FGFR2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FGFR2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3689 |
| Gene: |
FGFR2 |
More about : FGFR2 |
| Long gene name: |
fibroblast growth factor receptor 2 |
| Synonyms gene: |
KGFR BEK CFD1 JWS |
| Synonyms gene name: |
bacteria-expressed kinase keratinocyte growth factor receptor craniofacial dysostosis 1 Jackson-Weiss syndrome |
| Synonyms: |
CEK3 TK14 TK25 ECT1 K-SAM CD332 |
| Synonyms name: |
Crouzon syndrome Pfeiffer syndrome |
| Locus: |
10q26, 13 |
| Discovery year: |
1991-05-09 |
| GenBank acession: |
AK026508 |
| Entrez gene record: |
2263 |
| RefSeq identity: |
NM_022976 NM_000141 |
| Classification: |
I-set domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000019175 |
| Locus Specific Databases: |
LRG_994 |