| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SRC-1 (NCOA1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the SRC-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This SRC-1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q15788 |
| Purity: |
Purified |
| Description: |
It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, This protein binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion, as well as bHLH and PAS domains, SRC-1/NCOA1 acts as a transcriptional coactivator for steroid and nuclear hormone receptors |
| Immunogen: |
A portion of amino acids 1338-1367 from the human protein was used as the immunogen for this SRC-1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SRC-1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SRC-1 (NCOA1) |
| Short name: |
SRC-1 Antibody (NCOA1) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-1 (Antibody to) (NCOA1) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ASV and c-SRC and p60-Src and SRC1, BT, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0046628 and positive regulation of insulin receptor signaling pathway and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046875 and ephrin receptor binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048477 and oogenesis and biological process this GO :0050715 and positive regulation of cytokine secretion and biological process this GO :0050839 and cell adhesion molecule binding and molecular function this GO :0050847 and progesterone receptor signaling pathway and biological process this GO :0050900 and leukocyte migration and biological process this GO :0051219 and phosphoprotein binding and molecular function this GO :0051222 and positive regulation of protein transport and biological process this GO :0051385 and response to mineralocorticoid and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0051895 and negative regulation of focal adhesion assembly and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0051902 and negative regulation of mitochondrial depolarization and biological process this GO :0060065 and uterus development and biological process this GO :0060444 and branching involved in mammary gland duct morphogenesis and biological process this GO :0061024 and membrane organization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0070542 and response to fatty acid and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0070851 and growth factor receptor binding and molecular function this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071393 and cellular response to progesterone stimulus and biological process this GO :0071398 and cellular response to fatty acid and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071803 and positive regulation of podosome assembly and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process this GO :1902533 and positive regulation of intracellular signal transduction and biological process this GO :2000573 and positive regulation of DNA biosynthetic process and biological process this GO :2000811 and negative regulation of anoikis and biological process this GO :2001237 and negative regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process, SRC and IDBG-74081 and ENSG00000197122 and 6714, Src and IDBG-211273 and ENSMUSG00000027646 and 20779, nuclei, this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005158 and insulin receptor binding and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005764 and lysosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007049 and cell cycle and biological process this GO :0007155 and cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007172 and signal complex assembly and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0009615 and response to virus and biological process this GO :0010447 and response to acidity and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0010641 and positive regulation of platelet-derived growth factor receptor signaling pathway and biological process this GO :0010907 and positive regulation of glucose metabolic process and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0014911 and positive regulation of smooth muscle cell migration and biological process this GO :0016032 and viral process and biological process this GO :0016301 and kinase activity and molecular function this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0016477 and cell migration and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004715 : non-membrane spanning protein tyrosine kinase activity and also this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005080 : protein kinase C binding and also this GO :0005102 : receptor binding and also this GO :0005158 : insulin receptor binding and also this GO :0005178 : integrin binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004715 : non-membrane spanning protein tyrosine kinase activity, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005080 : protein kinase C binding, this GO :0005102 : receptor binding, this GO :0005158 : insulin receptor binding, this GO :0005178 : integrin binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0019899 : enzyme binding, this GO :0019901 : protein kinase binding, this GO :0019904 : protein domain specific binding, this GO :0020037 : heme binding, this GO :0030331 : estrogen receptor binding, this GO :0032403 : protein complex binding, this GO :0042169 : SH2 domain binding, this GO :0044325 : ion channel binding, this GO :0046875 : ephrin receptor binding, this GO :0050839 : cell adhesion molecule binding, this GO :0051219 : phosphoprotein binding, this GO :0070851 : growth factor receptor binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019899 : enzyme binding and also this GO :0019901 : protein kinase binding and also this GO :0019904 : protein domain specific binding and also this GO :0020037 : heme binding and also this GO :0030331 : estrogen receptor binding and also this GO :0032403 : protein complex binding and also this GO :0042169 : SH2 domain binding and also this GO :0044325 : ion channel binding and also this GO :0046875 : ephrin receptor binding and also this GO :0050839 : cell adhesion molecule binding and also this GO :0051219 : phosphoprotein binding and also this GO :0070851 : growth factor receptor binding, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0019904 and protein domain specific binding and molecular function this GO :0020037 and heme binding and molecular function this GO :0030168 and platelet activation and biological process this GO :0030331 and estrogen receptor binding and molecular function this GO :0030900 and forebrain development and biological process this GO :0031295 and T cell costimulation and biological process this GO :0031667 and response to nutrient levels and biological process this GO :0031954 and positive regulation of protein autophosphorylation and biological process this GO :0032148 and activation of protein kinase B activity and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032463 and negative regulation of protein homooli this GO merization and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0033146 and regulation of intracellular estrogen receptor signaling pathway and biological process this GO :0033625 and positive regulation of integrin activation and biological process this GO :0034332 and adherens junction organization and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0042493 and response to drug and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0043005 and neuron projection and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043114 and regulation of vascular permeability and biological process this GO :0043154 and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043393 and regulation of protein binding and biological process this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0044325 and ion channel binding and molecular function this GO :0045056 and transcytosis and biological process this GO :0045087 and innate immune response and biological process this GO :0045124 and regulation of bone resorption and biological process this GO :0045453 and bone resorption and biological process this GO :0045737 and positive regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0045892 and negative regulation of transcription, 61976 and IDBG-642561 and ENSBTAG00000008938 and 535742, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
| Identity: |
7668 |
| Gene: |
NCOA1 |
More about : NCOA1 |
| Long gene name: |
nuclear receptor coactivator 1 |
| Synonyms: |
SRC1 F-SRC-1 NCoA-1 KAT13A RIP160 bHLHe74 |
| Locus: |
2p23, 3 |
| Discovery year: |
1999-12-17 |
| GenBank acession: |
U40396 |
| Entrez gene record: |
8648 |
| Pubmed identfication: |
7481822 9575154 |
| RefSeq identity: |
NM_147223 |
| Classification: |
Basic helix-loop-helix proteins Lysine acetyltransferases |
| Havana BLAST/BLAT: |
OTTHUMG00000125523 |