| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SRC-1 (NCOA1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the SRC-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This SRC-1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q15788 |
| Purity: |
Purified |
| Description: |
Also involved in coactivation mediated by STAT3, Displays histone acetyltransferase activity toward H3 and H4, GR and ER), Involved in the coactivation of different nuclear receptors, Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3, Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, Required for mediating steroid hormone response, Required with NCOA2 to control energy balance between white and brown adipose tissues, STAT5A, STAT5B and STAT6 transcription factors, [UniProt], and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors, retinoids (RXRs), such as for steroids (PGR, the relevance of such activity remains however unclear, thyroid hormone (TRs) and prostanoids (PPARs), SRC-1/NCOA1 is a nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion |
| Immunogen: |
A portion of amino acids 186-214 from the human protein was used as the immunogen for this SRC-1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SRC-1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SRC-1 (NCOA1) |
| Short name: |
SRC-1 Antibody (NCOA1) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-1 (Antibody to) (NCOA1) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ASV and c-SRC and p60-Src and SRC1, BT, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0046628 and positive regulation of insulin receptor signaling pathway and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046875 and ephrin receptor binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048477 and oogenesis and biological process this GO :0050715 and positive regulation of cytokine secretion and biological process this GO :0050839 and cell adhesion molecule binding and molecular function this GO :0050847 and progesterone receptor signaling pathway and biological process this GO :0050900 and leukocyte migration and biological process this GO :0051219 and phosphoprotein binding and molecular function this GO :0051222 and positive regulation of protein transport and biological process this GO :0051385 and response to mineralocorticoid and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0051895 and negative regulation of focal adhesion assembly and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0051902 and negative regulation of mitochondrial depolarization and biological process this GO :0060065 and uterus development and biological process this GO :0060444 and branching involved in mammary gland duct morphogenesis and biological process this GO :0061024 and membrane organization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0070542 and response to fatty acid and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0070851 and growth factor receptor binding and molecular function this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071393 and cellular response to progesterone stimulus and biological process this GO :0071398 and cellular response to fatty acid and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071803 and positive regulation of podosome assembly and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process this GO :1902533 and positive regulation of intracellular signal transduction and biological process this GO :2000573 and positive regulation of DNA biosynthetic process and biological process this GO :2000811 and negative regulation of anoikis and biological process this GO :2001237 and negative regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process, SRC and IDBG-74081 and ENSG00000197122 and 6714, Src and IDBG-211273 and ENSMUSG00000027646 and 20779, nuclei, this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005158 and insulin receptor binding and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005764 and lysosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007049 and cell cycle and biological process this GO :0007155 and cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007172 and signal complex assembly and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0009615 and response to virus and biological process this GO :0010447 and response to acidity and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0010641 and positive regulation of platelet-derived growth factor receptor signaling pathway and biological process this GO :0010907 and positive regulation of glucose metabolic process and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0014911 and positive regulation of smooth muscle cell migration and biological process this GO :0016032 and viral process and biological process this GO :0016301 and kinase activity and molecular function this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0016477 and cell migration and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004715 : non-membrane spanning protein tyrosine kinase activity and also this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005080 : protein kinase C binding and also this GO :0005102 : receptor binding and also this GO :0005158 : insulin receptor binding and also this GO :0005178 : integrin binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004715 : non-membrane spanning protein tyrosine kinase activity, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005080 : protein kinase C binding, this GO :0005102 : receptor binding, this GO :0005158 : insulin receptor binding, this GO :0005178 : integrin binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0019899 : enzyme binding, this GO :0019901 : protein kinase binding, this GO :0019904 : protein domain specific binding, this GO :0020037 : heme binding, this GO :0030331 : estrogen receptor binding, this GO :0032403 : protein complex binding, this GO :0042169 : SH2 domain binding, this GO :0044325 : ion channel binding, this GO :0046875 : ephrin receptor binding, this GO :0050839 : cell adhesion molecule binding, this GO :0051219 : phosphoprotein binding, this GO :0070851 : growth factor receptor binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019899 : enzyme binding and also this GO :0019901 : protein kinase binding and also this GO :0019904 : protein domain specific binding and also this GO :0020037 : heme binding and also this GO :0030331 : estrogen receptor binding and also this GO :0032403 : protein complex binding and also this GO :0042169 : SH2 domain binding and also this GO :0044325 : ion channel binding and also this GO :0046875 : ephrin receptor binding and also this GO :0050839 : cell adhesion molecule binding and also this GO :0051219 : phosphoprotein binding and also this GO :0070851 : growth factor receptor binding, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0019904 and protein domain specific binding and molecular function this GO :0020037 and heme binding and molecular function this GO :0030168 and platelet activation and biological process this GO :0030331 and estrogen receptor binding and molecular function this GO :0030900 and forebrain development and biological process this GO :0031295 and T cell costimulation and biological process this GO :0031667 and response to nutrient levels and biological process this GO :0031954 and positive regulation of protein autophosphorylation and biological process this GO :0032148 and activation of protein kinase B activity and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032463 and negative regulation of protein homooli this GO merization and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0033146 and regulation of intracellular estrogen receptor signaling pathway and biological process this GO :0033625 and positive regulation of integrin activation and biological process this GO :0034332 and adherens junction organization and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0042493 and response to drug and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0043005 and neuron projection and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043114 and regulation of vascular permeability and biological process this GO :0043154 and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043393 and regulation of protein binding and biological process this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0044325 and ion channel binding and molecular function this GO :0045056 and transcytosis and biological process this GO :0045087 and innate immune response and biological process this GO :0045124 and regulation of bone resorption and biological process this GO :0045453 and bone resorption and biological process this GO :0045737 and positive regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0045892 and negative regulation of transcription, 61976 and IDBG-642561 and ENSBTAG00000008938 and 535742, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
| Identity: |
7668 |
| Gene: |
NCOA1 |
More about : NCOA1 |
| Long gene name: |
nuclear receptor coactivator 1 |
| Synonyms: |
SRC1 F-SRC-1 NCoA-1 KAT13A RIP160 bHLHe74 |
| Locus: |
2p23, 3 |
| Discovery year: |
1999-12-17 |
| GenBank acession: |
U40396 |
| Entrez gene record: |
8648 |
| Pubmed identfication: |
7481822 9575154 |
| RefSeq identity: |
NM_147223 |
| Classification: |
Basic helix-loop-helix proteins Lysine acetyltransferases |
| Havana BLAST/BLAT: |
OTTHUMG00000125523 |