| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
DYRK1A |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:2000 |
| Notes: |
Titration of the DYRK1A antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This DYRK1A antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13627 |
| Purity: |
Purified |
| Description: |
It catalyzes its autophosphorylation on serine/threonine and tyrosine residues, It is localized in the Down syndrome critical region of chromosome 21, It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development, The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene, This member contains a nuclear targeting signal sequence, a leucine zipper motif, a protein kinase domain, and a highly conservative 13-consecutive-histidine repeat, and is considered to be a strong candidate gene for learning defects associated with Down syndrome, DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family |
| Immunogen: |
A portion of amino acids 107-136 from the human protein was used as the immunogen for this DYRK1A antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the DYRK1A antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
DYRK1A |
| Short name: |
DYRK1A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DYRK1A (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3091 |
| Gene: |
DYRK1A |
More about : DYRK1A |
| Long gene name: |
dual specificity tyrosine phosphorylation regulated kinase 1A |
| Synonyms gene: |
DYRK1 DYRK MNBH |
| Synonyms gene name: |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
| Locus: |
21q22, 13 |
| Discovery year: |
1999-01-29 |
| GenBank acession: |
U52373 |
| Entrez gene record: |
1859 |
| Pubmed identfication: |
9284911 |
| RefSeq identity: |
NM_001396 |
| Havana BLAST/BLAT: |
OTTHUMG00000086657 |