| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Anti-PCSK9 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB, IHC |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:10-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the anti-PCSK9 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points |
| Intented use: |
This anti-PCSK9 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q8NBP7 |
| Purity: |
Purified |
| Description: |
The protein may function as a proprotein convertase, The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons, This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family |
| Immunogen: |
A portion of amino acids 479-508 from the human protein was used as the immunogen for this anti-PCSK9 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot the anti-PCSK9 antibody and store frozen at -20 deg, Store at 4oC for up to one month |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PCSK9 |
| Short name: |
Anti-PCSK9 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-proprotein convertase subtilisin/kexin classification 9 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, PCSK9 and IDBG-99082 and ENSG00000169174 and 255738, Pcsk9 and IDBG-170186 and ENSMUSG00000044254 and 100102, this GO :0001822 and kidney development and biological process this GO :0001889 and liver development and biological process this GO :0001920 and negative regulation of receptor recycling and biological process this GO :0002092 and positive regulation of receptor internalization and biological process this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005791 and rough endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006508 and proteolysis and biological process this GO :0006641 and triglyceride metabolic process and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0007041 and lysosomal transport and biological process this GO :0008203 and cholesterol metabolic process and biological process this GO :0009267 and cellular response to starvation and biological process this GO :0009986 and cell surface and cellular component this GO :0010469 and regulation of receptor activity and biological process this GO :0010989 and negative regulation of low-density lipoprotein particle clearance and biological process this GO :0016485 and protein processing and biological process this GO :0016540 and protein autoprocessing and biological process this GO :0019871 and sodium channel inhibitor activity and molecular function this GO :0022008 and neurogenesis and biological process this GO :0030134 and ER to this GO lgi transport vesicle and cellular component this GO :0030169 and low-density lipoprotein particle binding and molecular function this GO :0030182 and neuron differentiation and biological process this GO :0031232 and extrinsic component of external side of plasma membrane and cellular component this GO :0032799 and low-density lipoprotein receptor particle metabolic process and biological process this GO :0032802 and low-density lipoprotein particle receptor catabolic process and biological process this GO :0032803 and regulation of low-density lipoprotein particle receptor catabolic process and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0034185 and apolipoprotein binding and molecular function this GO :0034189 and very-low-density lipoprotein particle binding and molecular function this GO :0034190 and apolipoprotein receptor binding and molecular function this GO :0042157 and lipoprotein metabolic process and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0043523 and regulation of neuron apoptotic process and biological process this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0043621 and protein self-association and molecular function this GO :0044822 and poly(A) RNA binding and molecular function this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050750 and low-density lipoprotein particle receptor binding and molecular function this GO :0070326 and very-low-density lipoprotein particle receptor binding and molecular function, this GO :0004252 : serine-type endopeptidase activity, this GO :0004252 : serine-type endopeptidase activity and also this GO :0005515 : protein binding and also this GO :0019871 : sodium channel inhibitor activity and also this GO :0030169 : low-density lipoprotein particle binding and also this GO :0034185 : apolipoprotein binding and also this GO :0034189 : very-low-density lipoprotein particle binding and also this GO :0034190 : apolipoprotein receptor binding and also this GO :0043621 : protein self-association and also this GO :0044822 : poly(A) RNA binding and also this GO :0050750 : low-density lipoprotein particle receptor binding and also this GO :0070326 : very-low-density lipoprotein particle receptor binding, this GO :0005515 : protein binding, this GO :0019871 : sodium channel inhibitor activity, this GO :0030169 : low-density lipoprotein particle binding, this GO :0034185 : apolipoprotein binding, this GO :0034189 : very-low-density lipoprotein particle binding, this GO :0034190 : apolipoprotein receptor binding, this GO :0043621 : protein self-association, this GO :0044822 : poly(A) RNA binding, this GO :0050750 : low-density lipoprotein particle receptor binding, this GO :0070326 : very-low-density lipoprotein particle receptor binding, very-low-density lipoprotein particle receptor binding, proprotein convertase subtilisin/kexin type 9 |
| Identity: |
20001 |
| Gene: |
PCSK9 |
More about : PCSK9 |
| Long gene name: |
proprotein convertase subtilisin/kexin type 9 |
| Synonyms gene: |
HCHOLA3 |
| Synonyms gene name: |
autosomal dominant 3 , hypercholesterolemia |
| Synonyms: |
NARC-1 FH3 |
| Locus: |
1p32, 3 |
| Discovery year: |
2003-05-13 |
| GenBank acession: |
AX207686 |
| Entrez gene record: |
255738 |
| Pubmed identfication: |
12552133 12730697 |
| RefSeq identity: |
NM_174936 |
| Classification: |
Proprotein convertase subtilisin/kexin family |
| Havana BLAST/BLAT: |
OTTHUMG00000008136 |
| Locus Specific Databases: |
British Heart Foundation LRG_275 |