| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Megalin |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100 |
| Notes: |
Titration of the Megalin antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Megalin antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P98164 |
| Purity: |
Purified |
| Description: |
All LRPs are expressed in the central nervous system and, LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes (2), LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis, Structurally, The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, a member of the LDL receptor family, and cell migration (1), animal models have shown that they are indispensable for successful neurodevelopment, as well as cargo transport, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, for most receptors, members of the LDLR family share homology within their extracellular domains, protease clearance, the function most commonly attributed to this gene family (3), which are highlighted by the presence of clusters of ligand-binding repeats, Low density lipoprotein (LDL) receptor-related protein (LRP) |
| Immunogen: |
A portion of amino acids 4626-4655 from the human protein was used as the immunogen for this Megalin antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Megalin antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Megalin |
| Short name: |
Megalin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Megalin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6694 |
| Gene: |
LRP2 |
More about : LRP2 |
| Long gene name: |
LDL receptor related protein 2 |
| Synonyms gene name: |
low density lipoprotein receptor-related protein 2 |
| Synonyms: |
gp330 DBS |
| Synonyms name: |
megalin |
| Locus: |
2q31, 1 |
| Discovery year: |
1994-05-04 |
| Entrez gene record: |
4036 |
| Pubmed identfication: |
7959795 |
| RefSeq identity: |
NM_004525 |
| Classification: |
Low density lipoprotein receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000132179 |