| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
LRP2 (Megalin) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100 |
| Notes: |
Titration of the Megalin antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Megalin antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P98164 |
| Purity: |
Purified |
| Description: |
All LRPs are expressed in the central nervous system and, LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes (2), LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis, Structurally, The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, a member of the LDL receptor family, and cell migration (1), animal models have shown that they are indispensable for successful neurodevelopment, as well as cargo transport, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, for most receptors, members of the LDLR family share homology within their extracellular domains, protease clearance, the function most commonly attributed to this gene family (3), which are highlighted by the presence of clusters of ligand-binding repeats, Low density lipoprotein (LDL) receptor-related protein (LRP) |
| Immunogen: |
A portion of amino acids 4626-4655 from the human protein was used as the immunogen for this Megalin antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Megalin antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
LRP2 (Megalin) |
| Short name: |
LRP2 Antibody (Megalin) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
low density lipoprotein receptor-related protein 2 (Antibody to) (Megalin) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DBS and GP330, LRP2 and IDBG-640945 and ENSBTAG00000004555 and 100337021, LRP2 and IDBG-74420 and ENSG00000081479 and 4036, Lrp2 and IDBG-176227 and ENSMUSG00000027070 and 14725, Plasma membranes, SH3 domain binding, this GO :0001523 and retinoid metabolic process and biological process this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005764 and lysosome and cellular component this GO :0005765 and lysosomal membrane and cellular component this GO :0005768 and endosome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005903 and brush border and cellular component this GO :0005905 and coated pit and cellular component this GO :0006486 and protein glycosylation and biological process this GO :0006629 and lipid metabolic process and biological process this GO :0006766 and vitamin metabolic process and biological process this GO :0006897 and endocytosis and biological process this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0007603 and phototransduction, this GO :0005509 : calcium ion binding, this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0017124 : SH3 domain binding, this GO :0005515 : protein binding, this GO :0017124 : SH3 domain binding, visible light and biological process this GO :0008202 and steroid metabolic process and biological process this GO :0008283 and cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0017124 and SH3 domain binding and molecular function this GO :0030139 and endocytic vesicle and cellular component this GO :0030900 and forebrain development and biological process this GO :0031526 and brush border membrane and cellular component this GO :0042359 and vitamin D metabolic process and biological process this GO :0043235 and receptor complex and cellular component this GO :0044281 and small molecule metabolic process and biological process this GO :0045177 and apical part of cell and cellular component this GO :0070062 and extracellular vesicular exosome and cellular component, low density lipoprotein receptor-related protein 2 |
| Identity: |
6694 |
| Gene: |
LRP2 |
More about : LRP2 |
| Long gene name: |
LDL receptor related protein 2 |
| Synonyms gene name: |
low density lipoprotein receptor-related protein 2 |
| Synonyms: |
gp330 DBS |
| Synonyms name: |
megalin |
| Locus: |
2q31, 1 |
| Discovery year: |
1994-05-04 |
| Entrez gene record: |
4036 |
| Pubmed identfication: |
7959795 |
| RefSeq identity: |
NM_004525 |
| Classification: |
Low density lipoprotein receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000132179 |