| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ABCB11 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the ABCB11 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This ABCB11 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O95342 |
| Purity: |
Purified |
| Description: |
ABCB11 is a multifunctional polypeptide with two homologus halves, Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease, Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2), It is expressed predominatly, PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity, Structurally, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes, ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes |
| Immunogen: |
A portion of amino acids 1038-1067 from the human protein was used as the immunogen for this ABCB11 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the ABCB11 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ABCB11 |
| Short name: |
ABCB11 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ABCB11 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
42 |
| Gene: |
ABCB11 |
More about : ABCB11 |
| Long gene name: |
ATP binding cassette subfamily B member 11 |
| Synonyms gene: |
BSEP PFIC2 |
| Synonyms gene name: |
member 11 , progressive familial intrahepatic cholestasis 2 bile salt export pump ATP-binding cassette, sub-family B (MDR/TAP) |
| Synonyms: |
ABC16 SPGP PFIC-2 PGY4 |
| Synonyms name: |
ABC member 16, MDR/TAP subfamily |
| Locus: |
2q31, 1 |
| Discovery year: |
1998-09-25 |
| GenBank acession: |
AF091582 |
| Entrez gene record: |
8647 |
| Pubmed identfication: |
9806540 |
| RefSeq identity: |
NM_003742 |
| Classification: |
ATP binding cassette subfamily B |
| Havana BLAST/BLAT: |
OTTHUMG00000154039 |
| Locus Specific Databases: |
CCHMC-BMI &, UC Hearing Loss Mutation Database |