| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ABCB11 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the ABCB11 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This ABCB11 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O95342 |
| Purity: |
Antigen affinity |
| Description: |
It is a member of the superfamily of ATP-binding cassette (ABC) transporters, It is mapped to chromosome 2q24, Mutation of the gene is associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) which causes an increases the risk of hepatocellular carcinoma in early life, The ABCB11 protein is mainly expressed in the liver, Bile Salt Export Pump (BSEP) is a protein which in humans is encoded by the ABCB11 gene |
| Immunogen: |
An amino acid sequence from the C-terminus of human ABCB11 (THEELMAQKGAYYKL) was used as the immunogen for this ABCB11 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ABCB11 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ABCB11 |
| Short name: |
ABCB11 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ABCB11 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
42 |
| Gene: |
ABCB11 |
More about : ABCB11 |
| Long gene name: |
ATP binding cassette subfamily B member 11 |
| Synonyms gene: |
BSEP PFIC2 |
| Synonyms gene name: |
member 11 , progressive familial intrahepatic cholestasis 2 bile salt export pump ATP-binding cassette, sub-family B (MDR/TAP) |
| Synonyms: |
ABC16 SPGP PFIC-2 PGY4 |
| Synonyms name: |
ABC member 16, MDR/TAP subfamily |
| Locus: |
2q31, 1 |
| Discovery year: |
1998-09-25 |
| GenBank acession: |
AF091582 |
| Entrez gene record: |
8647 |
| Pubmed identfication: |
9806540 |
| RefSeq identity: |
NM_003742 |
| Classification: |
ATP binding cassette subfamily B |
| Havana BLAST/BLAT: |
OTTHUMG00000154039 |
| Locus Specific Databases: |
CCHMC-BMI &, UC Hearing Loss Mutation Database |