| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
XRCC1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IF, IHC, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:50-1:100, Immunofluorescence: 1:25, Western blot: 1:1000 |
| Notes: |
Titration of the XRCC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This XRCC1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P18887 |
| Purity: |
Antigen affinity |
| Description: |
A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity, It may play a role in DNA processing during meiogenesis and recombination in germ cells, This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway, The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents |
| Immunogen: |
A portion of amino acids 407-435 from the human protein was used as the immunogen for this XRCC1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the XRCC1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
XRCC1 |
| Short name: |
XRCC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
X-ray repair complementing defective repair in Chinese hamster cells 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
RCC, XRCC1 and IDBG-55268 and ENSG00000073050 and 7515, XRCC1 and IDBG-639023 and ENSBTAG00000016268 and 616905, Xrcc1 and IDBG-155000 and ENSMUSG00000051768 and 22594, nuclei, protein binding, this GO :0000012 and single strand break repair and biological process this GO :0001666 and response to hypoxia and biological process this GO :0003684 and damaged DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0006281 and DNA repair and biological process this GO :0006284 and base-excision repair and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0010033 and response to organic substance and biological process this GO :0021766 and hippocampus development and biological process this GO :0042493 and response to drug and biological process, this GO :0003684 : damaged DNA binding, this GO :0003684 : damaged DNA binding and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, X-ray repair complementing defective repair in Chinese hamster cells 1 |
| Identity: |
12828 |
| Gene: |
XRCC1 |
More about : XRCC1 |
| Long gene name: |
X-ray repair cross complementing 1 |
| Synonyms gene: |
RCC |
| Synonyms gene name: |
X-ray repair complementing defective repair in Chinese hamster cells 1 |
| Locus: |
19q13, 2 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
M36089 |
| Entrez gene record: |
7515 |
| Pubmed identfication: |
2247054 |
| RefSeq identity: |
NM_006297 |
| Havana BLAST/BLAT: |
OTTHUMG00000182699 |
| Locus Specific Databases: |
LRG_784 |