| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HAS1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the HAS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This HAS1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q92839 |
| Purity: |
Antigen affinity |
| Description: |
Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis, HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts, HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, In addition, It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds, It serves a variety of functions, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase, and is a constituent of the extracellular matrix, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, and overexpression of HA receptors has been correlated with tumor metastasis, and provision of a matrix through which cells can migrate, and the chains are extruded through pore-like structures into the extracellular space, including space filling, lubrication of joints, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals |
| Immunogen: |
A portion of amino acids 166-193 from the human protein was used as the immunogen for this HAS1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the HAS1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HAS1 |
| Short name: |
HAS1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
hyaluronan synthase 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
HAS, HAS1 and IDBG-641414 and ENSBTAG00000017672 and 101907856, HAS1 and IDBG-66243 and ENSG00000105509 and 3036, Has1 and IDBG-141052 and ENSMUSG00000003665 and 15116, Plasma membranes, hyaluronan synthase activity, this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005975 and carbohydrate metabolic process and biological process this GO :0006024 and glycosaminoglycan biosynthetic process and biological process this GO :0007155 and cell adhesion and biological process this GO :0010764 and negative regulation of fibroblast migration and biological process this GO :0016020 and membrane and cellular component this GO :0030203 and glycosaminoglycan metabolic process and biological process this GO :0030212 and hyaluronan metabolic process and biological process this GO :0030213 and hyaluronan biosynthetic process and biological process this GO :0036120 and cellular response to platelet-derived growth factor stimulus and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045226 and extracellular polysaccharide biosynthetic process and biological process this GO :0050501 and hyaluronan synthase activity and molecular function this GO :0085029 and extracellular matrix assembly and biological process, this GO :0050501 : hyaluronan synthase activity, this GO :0050501 : hyaluronan synthase activity, 282820, hyaluronan synthase 1 |
| Identity: |
4818 |
| Gene: |
HAS1 |
More about : HAS1 |
| Long gene name: |
hyaluronan synthase 1 |
| Synonyms gene: |
HAS |
| Locus: |
19q13, 41 |
| Discovery year: |
1996-04-12 |
| GenBank acession: |
U59269 |
| Entrez gene record: |
3036 |
| Pubmed identfication: |
9169154 |
| RefSeq identity: |
NM_001523 |
| Classification: |
Glycosyltransferase family 2 |
| Havana BLAST/BLAT: |
OTTHUMG00000183499 |