| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Phospho-IKKB (pS689) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, DB |
| Recommended dilutions: |
Dot blot: 1:500 |
| Notes: |
Titration of the phospho-IKKB antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This phospho-IKKB antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O14920 |
| Purity: |
Antigen affinity |
| Description: |
Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, R is an A or G purine, RELA, The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), and Y is a C or T pyrimidine), or RELB to form the NFKB complex, or T, thereby allowing activation of the NF-kappa-B complex, which inactivate NF-kappa-B by trapping it in the cytoplasm, NFKB1 or NFKB2 is bound to REL |
| Immunogen: |
This phospho-IKKB antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS689 of human IKKB |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-IKKB antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Phospho-IKKB (pS689) |
| Short name: |
Phospho-IKKB Antibody (pS689) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
phosphorilated-IKKB (Antibody to) (pS689) |
| Alternative technique: |
antibodies |
| Identity: |
5960 |
| Gene: |
IKBKB |
More about : IKBKB |
| Long gene name: |
inhibitor of nuclear factor kappa B kinase subunit beta |
| Synonyms gene name: |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| Synonyms: |
IKK2 NFKBIKB IKK-beta IKKB |
| Locus: |
8p11, 21 |
| Discovery year: |
1998-02-11 |
| GenBank acession: |
AF029684 |
| Entrez gene record: |
3551 |
| Pubmed identfication: |
9878263 9763654 18308615 |
| Havana BLAST/BLAT: |
OTTHUMG00000164092 |