| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Phospho-MECP2 (pS292) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100 |
| Notes: |
Titration of the phospho-MECP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This phospho-MECP2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P51608 |
| Purity: |
Antigen affinity |
| Description: |
Each of these proteins, Human proteins MECP2, In contrast to other MBD family members, MBD1, MBD1 and MBD2 can also repress transcription from methylated gene promoters, MBD2, MBD3, MECP2, MECP2 gene mutations are the cause of some cases of Rett syndrome, MECP2 is X-linked and subject to X inactivation, MECP2 is dispensible in stem cells, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD), but is essential for embryonic development, is capable of binding specifically to methylated DNA, with the exception of MBD3, DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development |
| Immunogen: |
This phospho-MECP2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS292 of human MECP2 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-MECP2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Phospho-MECP2 (pS292) |
| Short name: |
Phospho-MECP2 Antibody (pS292) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
phosphorilated-MECP2 (Antibody to) (pS292) |
| Alternative technique: |
antibodies |
| Identity: |
6990 |
| Gene: |
MECP2 |
More about : MECP2 |
| Long gene name: |
methyl-CpG binding protein 2 |
| Synonyms gene: |
RTT MRX16 MRX79 |
| Synonyms gene name: |
X-linked 16 mental retardation, X-linked 79 Rett syndrome methyl CpG binding protein 2 (Rett syndrome) methyl CpG binding protein 2 , mental retardation |
| Locus: |
Xq28 |
| Discovery year: |
1996-09-03 |
| GenBank acession: |
AF158180 |
| Entrez gene record: |
4204 |
| Pubmed identfication: |
1606614 10508514 |
| RefSeq identity: |
NM_004992 |
| Classification: |
X-linked mental retardation Methyl-CpG binding domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000024229 |
| Locus Specific Databases: |
RettBASE Mental Retardation database LRG_764 |