| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
VE Cadherin (CDH5) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the VE Cadherin antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This VE Cadherin antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P33151 |
| Purity: |
Antigen affinity |
| Description: |
Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions, CDH5 is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer |
| Immunogen: |
A portion of amino acids 106-134 from the human protein was used as the immunogen for this VE Cadherin antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the VE Cadherin antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
VE Cadherin (CDH5) |
| Short name: |
VE Cadherin Antibody (CDH5) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
type 2 (vascular endothelium)), VE Cadherin (Antibody to) (cadherin 5 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
7B4 and CD144, BT, CDH5 and IDBG-34871 and ENSG00000179776 and 1003, Cdh5 and IDBG-185038 and ENSMUSG00000031871 and 12562, Cell surfaces, ion channel binding, this GO :0001955 and blood vessel maturation and biological process this GO :0005102 and receptor binding and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0005923 and tight junction and cellular component this GO :0007156 and homophilic cell adhesion and biological process this GO :0008013 and beta-catenin binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019903 and protein phosphatase binding and molecular function this GO :0030054 and cell junction and cellular component this GO :0034329 and cell junction assembly and biological process this GO :0034332 and adherens junction organization and biological process this GO :0044325 and ion channel binding and molecular function this GO :0045216 and cell-cell junction organization and biological process this GO :0071944 and cell periphery and cellular component this GO :2000114 and regulation of establishment of cell polarity and biological process, this GO :0005102 : receptor binding, this GO :0005102 : receptor binding and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0008013 : beta-catenin binding and also this GO :0019903 : protein phosphatase binding and also this GO :0044325 : ion channel binding, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0008013 : beta-catenin binding, this GO :0019903 : protein phosphatase binding, this GO :0044325 : ion channel binding, type 2 (vascular endothelium), 64659 and IDBG-633039 and ENSBTAG00000007421 and 414735, cadherin 5 |
| Identity: |
1764 |
| Gene: |
CDH5 |
More about : CDH5 |
| Long gene name: |
cadherin 5 |
| Synonyms gene name: |
VE-cadherin (vascular epithelium) cadherin 5, cadherin 5, type 2, type 2 (vascular endothelium) |
| Synonyms: |
7B4 CD144 |
| Synonyms name: |
VE-cadherin |
| Locus: |
16q21 |
| Discovery year: |
1992-11-20 |
| GenBank acession: |
X79981 |
| Entrez gene record: |
1003 |
| Pubmed identfication: |
2059658 |
| RefSeq identity: |
NM_001795 |
| Classification: |
Type II classical cadherins CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000137495 |