| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SDHB |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the SDHB antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This SDHB antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P21912 |
| Purity: |
Antigen affinity |
| Description: |
Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane, The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme, and support a link between mitochondrial dysfunction and tumorigenesis, carries electrons from FADH to CoQ, which is specifically involved in the oxidation of succinate, Complex II of the respiratory chain |
| Immunogen: |
A portion of amino acids 205-234 from the human protein was used as the immunogen for this SDHB antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SDHB antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SDHB |
| Short name: |
SDHB Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SDHB (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10681 |
| Gene: |
SDHB |
More about : SDHB |
| Long gene name: |
succinate dehydrogenase complex iron sulfur subunit B |
| Synonyms gene: |
SDH1 SDH |
| Synonyms gene name: |
iron sulfur (Ip) , iron sulfur (Ip) succinate dehydrogenase complex subunit B, subunit B, succinate dehydrogenase complex |
| Synonyms name: |
iron-sulfur subunit of complex II succinate dehydrogenase [ubiquinone] iron-sulfur subunit |
| Locus: |
1p36, 13 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
U17248 |
| Entrez gene record: |
6390 |
| RefSeq identity: |
NM_003000 |
| Classification: |
Mitochondrial complex II: succinate dehydrogenase subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000002289 |
| Locus Specific Databases: |
SDHB @ LOVD TCA Cycle Gene Mutation Database LRG_316 |