| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Anti-FOXP3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the anti-FOXP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This anti-FOXP3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9BZS1 |
| Purity: |
Antigen affinity |
| Description: |
Alternatively spliced transcript variants encoding different isoforms have been identified, Defects in this gene are the cause of immunodeficiency polyendocrinopathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome, enteropathy, Forkhead box P3 is a member of the forkhead/winged-helix family of transcriptional regulators |
| Immunogen: |
A portion of amino acids 397-423 from the human protein was used as the immunogen for this anti-FOXP3 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the anti-FOXP3 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
FOXP3 |
| Short name: |
Anti-FOXP3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-forkhead box P3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD25-positive, CD25-positive, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009615 and response to virus and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0031064 and negative regulation of histone deacetylation and biological process this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032689 and negative regulation of interferon-gamma production and biological process this GO :0032693 and negative regulation of interleukin-10 production and biological process this GO :0032703 and negative regulation of interleukin-2 production and biological process this GO :0032713 and negative regulation of interleukin-4 production and biological process this GO :0032714 and negative regulation of interleukin-5 production and biological process this GO :0032715 and negative regulation of interleukin-6 production and biological process this GO :0032720 and negative regulation of tumor necrosis factor production and biological process this GO :0032753 and positive regulation of interleukin-4 production and biological process this GO :0032792 and negative regulation of CREB transcription factor activity and biological process this GO :0032831 and positive regulation of CD4-positive, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046007 and negative regulation of activated T cell proliferation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048294 and negative regulation of isotype switching to IgE isotypes and biological process this GO :0048302 and regulation of isotype switching to IgG isotypes and biological process this GO :0050672 and negative regulation of lymphocyte proliferation and biological process this GO :0050710 and negative regulation of cytokine secretion and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0050777 and negative regulation of immune response and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0051059 and NF-kappaB binding and molecular function this GO :0051525 and NFAT protein binding and molecular function, FOXP3 and IDBG-637186 and ENSBTAG00000013279 and 506053, FOXP3 and IDBG-66215 and ENSG00000049768 and 50943, Foxp3 and IDBG-128986 and ENSMUSG00000039521 and 20371, NFAT protein binding, alpha-beta regulatory T cell differentiation and biological process this GO :0002456 and T cell mediated immunity and biological process this GO :0002507 and tolerance induction and biological process this GO :0002513 and tolerance induction to self antigen and biological process this GO :0002637 and regulation of immunoglobulin production and biological process this GO :0002666 and positive regulation of T cell tolerance induction and biological process this GO :0002669 and positive regulation of T cell anergy and biological process this GO :0002677 and negative regulation of chronic inflammatory response and biological process this GO :0002725 and negative regulation of T cell cytokine production and biological process this GO :0002851 and positive regulation of peripheral T cell tolerance induction and biological process this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003705 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006338 and chromatin remodeling and biological process this GO :0006355 and regulation of transcription, alpha-beta regulatory T cell differentiation and biological process this GO :0032914 and positive regulation of transforming growth factor beta1 production and biological process this GO :0033092 and positive regulation of immature T cell proliferation in thymus and biological process this GO :0035035 and histone acetyltransferase binding and molecular function this GO :0035066 and positive regulation of histone acetylation and biological process this GO :0035067 and negative regulation of histone acetylation and biological process this GO :0042036 and negative regulation of cytokine biosynthetic process and biological process this GO :0042110 and T cell activation and biological process this GO :0042130 and negative regulation of T cell proliferation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0042826 and histone deacetylase binding and molecular function this GO :0043029 and T cell homeostasis and biological process this GO :0043234 and protein complex and cellular component this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045066 and regulatory T cell differentiation and biological process this GO :0045077 and negative regulation of interferon-gamma biosynthetic process and biological process this GO :0045085 and negative regulation of interleukin-2 biosynthetic process and biological process this GO :0045591 and positive regulation of regulatory T cell differentiation and biological process this GO :0045892 and negative regulation of transcription, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001782 and B cell homeostasis and biological process this GO :0001816 and cytokine production and biological process this GO :0002262 and myeloid cell homeostasis and biological process this GO :0002361 and CD4-positive, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and also this GO :0003714 : transcription corepressor activity and also this GO :0005515 : protein binding and also this GO :0035035 : histone acetyltransferase binding and also this GO :0042803 : protein homodimerization activity and also this GO :0042826 : histone deacetylase binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046872 : metal ion binding and also this GO :0051059 : NF-kappaB binding and also this GO :0051525 : NFAT protein binding, this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, this GO :0003714 : transcription corepressor activity, this GO :0005515 : protein binding, this GO :0035035 : histone acetyltransferase binding, this GO :0042803 : protein homodimerization activity, this GO :0042826 : histone deacetylase binding, this GO :0043565 : sequence-specific DNA binding, this GO :0046872 : metal ion binding, this GO :0051059 : NF-kappaB binding, this GO :0051525 : NFAT protein binding, forkhead box P3 |
| Identity: |
6106 |
| Gene: |
FOXP3 |
More about : FOXP3 |
| Long gene name: |
forkhead box P3 |
| Synonyms gene: |
IPEX |
| Synonyms gene name: |
X-linked , enteropathy, immune dysregulation, polyendocrinopathy |
| Synonyms: |
JM2 XPID AIID PIDX DIETER SCURFIN |
| Locus: |
Xp11, 23 |
| Discovery year: |
2000-05-05 |
| Entrez gene record: |
50943 |
| Pubmed identfication: |
10677306 11138001 |
| RefSeq identity: |
NM_014009 |
| Classification: |
Forkhead boxes |
| Havana BLAST/BLAT: |
OTTHUMG00000024135 |
| Locus Specific Databases: |
FOXP3base: Mutation registry for Immunodysregulation, IPEX Mental Retardation database LRG_62 , X-linked, and enteropathy, polyendocrinopathy |