| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Leptin (LEP) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IF, IHC, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the LEP antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This LEP antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P41159 |
| Purity: |
Antigen affinity |
| Description: |
Mutations in this gene and/or its regulatory regions cause severe obesity, This gene has also been linked to type 2 diabetes mellitus development, This protein, This protein also has several endocrine functions, [provided by RefSeq], and is involved in the regulation of immune and inflammatory responses, and morbid obesity with hypogonadism, and which plays a major role in the regulation of body weight, angiogenesis and wound healing, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass, hematopoiesis, which acts through the leptin receptor, This gene encodes a protein that is secreted by white adipocytes |
| Immunogen: |
A portion of amino acids 8-37 from the human protein was used as the immunogen for this LEP antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the LEP antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene: |
LEP |
More about : LEP |
| Gene target: |
Leptin (LEP) |
| Short name: |
Leptin Antibody (LEP) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Leptin (Antibody to) (leptin) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, LEP and IDBG-39587 and ENSG00000174697 and 3952, LEPD and OB and OBS, Lep and IDBG-130781 and ENSMUSG00000059201 and 16846, OBESE and IDBG-635003 and ENSBTAG00000014911 and 280836, peptide hormone receptor binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001542 and ovulation from ovarian follicle and biological process this GO :0001666 and response to hypoxia and biological process this GO :0001819 and positive regulation of cytokine production and biological process this GO :0001890 and placenta development and biological process this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0002021 and response to dietary excess and biological process this GO :0005179 and hormone activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006006 and glucose metabolic process and biological process this GO :0006111 and regulation of gluconeogenesis and biological process this GO :0006112 and energy reserve metabolic process and biological process this GO :0006114 and glycerol biosynthetic process and biological process this GO :0006629 and lipid metabolic process and biological process this GO :0006635 and fatty acid beta-oxidation and biological process this GO :0007165 and signal transduction and biological process this GO :0007260 and tyrosine phosphorylation of STAT protein and biological process this GO :0007565 and female pregnancy and biological process this GO :0007584 and response to nutrient and biological process this GO :0007623 and circadian rhythm and biological process this GO :0008083 and growth factor activity and molecular function this GO :0008203 and cholesterol metabolic process and biological process this GO :0008206 and bile acid metabolic process and biological process this GO :0008217 and regulation of blood pressure and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008343 and adult feeding behavior and biological process this GO :0009062 and fatty acid catabolic process and biological process this GO :0009892 and negative regulation of metabolic process and biological process this GO :0019222 and regulation of metabolic process and biological process this GO :0021954 and central nervous system neuron development and biological process this GO :0030073 and insulin secretion and biological process this GO :0030300 and regulation of intestinal cholesterol absorption and biological process this GO :0032099 and negative regulation of appetite and biological process this GO :0032868 and response to insulin and biological process this GO :0033197 and response to vitamin E and biological process this GO :0033210 and leptin-mediated signaling pathway and biological process this GO :0033686 and positive regulation of luteinizing hormone secretion and biological process this GO :0035630 and bone mineralization involved in bone maturation and biological process this GO :0042307 and positive regulation of protein import into nucleus and biological process this GO :0042445 and hormone metabolic process and biological process this GO :0042517 and positive regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0042755 and eating behavior and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043270 and positive regulation of ion transport and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0045087 and innate immune response and biological process this GO :0045598 and regulation of fat cell differentiation and biological process this GO :0045639 and positive regulation of myeloid cell differentiation and biological process this GO :0045906 and negative regulation of vasoconstriction and biological process this GO :0046427 and positive regulation of JAK-STAT cascade and biological process this GO :0046628 and positive regulation of insulin receptor signaling pathway and biological process this GO :0046881 and positive regulation of follicle-stimulating hormone secretion and biological process this GO :0048639 and positive regulation of developmental growth and biological process this GO :0050796 and regulation of insulin secretion and biological process this GO :0050810 and regulation of steroid biosynthetic process and biological process this GO :0050901 and leukocyte tethering or rolling and biological process this GO :0051428 and peptide hormone receptor binding and molecular function this GO :0060587 and regulation of lipoprotein lipid oxidation and biological process this GO :0060612 and adipose tissue development and biological process this GO :0061037 and negative regulation of cartilage development and biological process this GO :0070093 and negative regulation of gluca this GO n secretion and biological process this GO :0071298 and cellular response to L-ascorbic acid and biological process this GO :0071300 and cellular response to retinoic acid and biological process this GO :2000366 and positive regulation of STAT protein import into nucleus and biological process this GO :2000486 and negative regulation of glutamine transport and biological process this GO :2000491 and positive regulation of hepatic stellate cell activation and biological process, this GO :0005179 : hormone activity, this GO :0005179 : hormone activity and also this GO :0005515 : protein binding and also this GO :0008083 : growth factor activity and also this GO :0051428 : peptide hormone receptor binding, this GO :0005515 : protein binding, this GO :0008083 : growth factor activity, this GO :0051428 : peptide hormone receptor binding, leptin |
| Identity: |
6553 |
| Long gene name: |
leptin |
| Synonyms gene: |
OBS OB |
| Synonyms gene name: |
leptin (murine obesity homolog) leptin (obesity homolog, mouse) |
| Locus: |
7q32, 1 |
| Discovery year: |
1993-01-26 |
| Entrez gene record: |
3952 |
| Pubmed identfication: |
1686014 16932309 |
| Havana BLAST/BLAT: |
OTTHUMG00000157564 |