| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SOX8 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the SOX8 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This SOX8 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P57073 |
| Purity: |
Antigen affinity |
| Description: |
Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome), The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins, This protein may be involved in brain development and function, This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate |
| Immunogen: |
A portion of amino acids 225-253 from the human protein was used as the immunogen for this SOX8 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SOX8 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SOX8 |
| Short name: |
SOX8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SRY (sex determining region Y)-box 8 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0007165 and signal transduction and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007422 and peripheral nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008584 and male this GO nad development and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0010817 and regulation of hormone levels and biological process this GO :0014015 and positive regulation of gliogenesis and biological process this GO :0033690 and positive regulation of osteoblast proliferation and biological process this GO :0035914 and skeletal muscle cell differentiation and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044798 and nuclear transcription factor complex and cellular component this GO :0045165 and cell fate commitment and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0045662 and negative regulation of myoblast differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046533 and negative regulation of photoreceptor cell differentiation and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048469 and cell maturation and biological process this GO :0048484 and enteric nervous system development and biological process this GO :0048709 and oli this GO dendrocyte differentiation and biological process this GO :0060009 and Sertoli cell development and biological process this GO :0060018 and astrocyte fate commitment and biological process this GO :0060041 and retina development in camera-type eye and biological process this GO :0060221 and retinal rod cell differentiation and biological process this GO :0060612 and adipose tissue development and biological process this GO :0061138 and morphogenesis of a branching epithelium and biological process this GO :0072034 and renal vesicle induction and biological process this GO :0072197 and ureter morphogenesis and biological process this GO :0072289 and metanephric nephron tubule formation and biological process this GO :0090184 and positive regulation of kidney development and biological process this GO :0090190 and positive regulation of branching involved in ureteric bud morphogenesis and biological process, SOX8 and IDBG-634123 and ENSBTAG00000020737 and 530317, SOX8 and IDBG-8450 and ENSG00000005513 and 30812, Sox8 and IDBG-152312 and ENSMUSG00000024176 and 20681, nuclei, protein heterodimerization activity, this GO :0000979 and RNA polymerase II core promoter sequence-specific DNA binding and molecular function this GO :0000981 and sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0001649 and osteoblast differentiation and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001755 and neural crest cell migration and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006351 and transcription, this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding, this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding and also this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046982 : protein heterodimerization activity, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0043565 : sequence-specific DNA binding, this GO :0046982 : protein heterodimerization activity, SRY (sex determining region Y)-box 8 |
| Identity: |
11203 |
| Gene: |
SOX8 |
More about : SOX8 |
| Long gene name: |
SRY-box 8 |
| Synonyms gene name: |
SRY (sex determining region Y)-box 8 SRY box 8 |
| Locus: |
16p13, 3 |
| Discovery year: |
2000-03-14 |
| GenBank acession: |
AF164104 |
| Entrez gene record: |
30812 |
| Pubmed identfication: |
10662550 10684944 |
| Classification: |
SRY-boxes |
| Havana BLAST/BLAT: |
OTTHUMG00000122101 |