| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Aurkb |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the Aurkb antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Aurkb antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O70126 |
| Purity: |
Antigen affinity |
| Description: |
Component of the chromosomal passenger complex (CPC), Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis, Required for kinetochore localization of BUB1 and SGOL1 (By similarity), The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity), a complex that acts as a key regulator of mitosis, Aurkb may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis |
| Immunogen: |
A portion of amino acids 84-111 from the mouse protein was used as the immunogen for this Aurkb antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Aurkb antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Aurkb |
| Short name: |
Aurkb Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
aurora kinase B (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11390 |
| Gene: |
AURKB |
More about : AURKB |
| Long gene name: |
aurora kinase B |
| Synonyms gene: |
STK12 |
| Synonyms gene name: |
serine/threonine kinase 12 |
| Synonyms: |
Aik2 IPL1 AurB AIM-1 ARK2 STK5 PPP1R48 |
| Synonyms name: |
aurora-B aurora-1 protein phosphatase 1, regulatory subunit 48 |
| Locus: |
17p13, 1 |
| Discovery year: |
1999-01-29 |
| GenBank acession: |
AF004022 |
| Entrez gene record: |
9212 |
| Pubmed identfication: |
9858806 |
| RefSeq identity: |
NM_004217 |
| Classification: |
Protein phosphatase 1 regulatory subunits Chromosomal passenger complex |
| Havana BLAST/BLAT: |
OTTHUMG00000108189 |