| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
RUNX3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IF, WB, IHC |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the RUNX3 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This RUNX3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13761 |
| Purity: |
Antigen affinity |
| Description: |
A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, It also interacts with other transcription factors, It functions as a tumor suppressor, Multiple transcript variants encoding different isoforms have been found for this gene, and can either activate or suppress transcription, and the gene is frequently deleted or transcriptionally silenced in cancer, This gene encodes a member of the runt domain-containing family of transcription factors |
| Immunogen: |
A portion of amino acids 168-197 from the human protein was used as the immunogen for this RUNX3 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the RUNX3 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
RUNX3 |
| Short name: |
RUNX3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
runt-related transcription factor 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AML2 and CBFA3 and PEBP2aC, ATP binding, DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007411 and axon guidance and biological process this GO :0031069 and hair follicle morphogenesis and biological process this GO :0031175 and neuron projection development and biological process this GO :0032609 and interferon-gamma production and biological process this GO :0045087 and innate immune response and biological process this GO :0045786 and negative regulation of cell cycle and biological process this GO :0048469 and cell maturation and biological process this GO :0048935 and peripheral nervous system neuron development and biological process this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process, RUNX3 and IDBG-645327 and ENSBTAG00000019800 and 617389, RUNX3 and IDBG-94257 and ENSG00000020633 and 864, Runx3 and IDBG-196773 and ENSMUSG00000070691 and 12399, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000790 and nuclear chromatin and cellular component this GO :0000977 and RNA polymerase II regulatory region sequence-specific DNA binding and molecular function this GO :0000981 and sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0002062 and chondrocyte differentiation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006355 and regulation of transcription, this GO :0000977 : RNA polymerase II regulatory region sequence-specific DNA binding, this GO :0000977 : RNA polymerase II regulatory region sequence-specific DNA binding and also this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, runt-related transcription factor 3 |
| Identity: |
10473 |
| Gene: |
RUNX3 |
More about : RUNX3 |
| Long gene name: |
runt related transcription factor 3 |
| Synonyms gene: |
CBFA3 |
| Synonyms gene name: |
runt-related transcription factor 3 |
| Synonyms: |
AML2 PEBP2A3 |
| Locus: |
1p36, 11 |
| Discovery year: |
1994-11-02 |
| GenBank acession: |
BC013362 |
| Entrez gene record: |
864 |
| Pubmed identfication: |
7835892 |
| RefSeq identity: |
NM_004350 |
| Havana BLAST/BLAT: |
OTTHUMG00000003316 |