| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Anti-TLR8 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the anti-TLR8 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This anti-TLR8 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9NR97 |
| Purity: |
Antigen affinity |
| Description: |
TLR7, TLRs are highly conserved from Drosophila to humans and share structural and functional similarities, The various TLRs exhibit different patterns of expression, They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, and mediate the production of cytokines necessary for the development of effective immunity, on chromosome X, The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity |
| Immunogen: |
A portion of amino acids 434-463 from the human protein was used as the immunogen for this anti-TLR8 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the anti-TLR8 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TLR8 |
| Short name: |
Anti-TLR8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-toll-like receptor 8 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, TLR8 and IDBG-44288 and ENSG00000101916 and 51311, Tlr8 and IDBG-185523 and ENSMUSG00000040522 and 170744, drug binding, this GO :0000139 and this GO lgi membrane and cellular component this GO :0001774 and microglial cell activation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0003677 and DNA binding and molecular function this GO :0003723 and RNA binding and molecular function this GO :0003725 and double-stranded RNA binding and molecular function this GO :0003727 and single-stranded RNA binding and molecular function this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0008144 and drug binding and molecular function this GO :0009615 and response to virus and biological process this GO :0010008 and endosome membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016064 and immunoglobulin mediated immune response and biological process this GO :0034158 and toll-like receptor 8 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0036020 and endolysosome membrane and cellular component this GO :0045078 and positive regulation of interferon-gamma biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045089 and positive regulation of innate immune response and biological process this GO :0045356 and positive regulation of interferon-alpha biosynthetic process and biological process this GO :0045359 and positive regulation of interferon-beta biosynthetic process and biological process this GO :0045416 and positive regulation of interleukin-8 biosynthetic process and biological process this GO :0050707 and regulation of cytokine secretion and biological process this GO :0051607 and defense response to virus and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003723 : RNA binding and also this GO :0003725 : double-stranded RNA binding and also this GO :0003727 : single-stranded RNA binding and also this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0008144 : drug binding, this GO :0003723 : RNA binding, this GO :0003725 : double-stranded RNA binding, this GO :0003727 : single-stranded RNA binding, this GO :0004872 : receptor activity, this GO :0005515 : protein binding, this GO :0008144 : drug binding, toll-like receptor 8 |
| Identity: |
15632 |
| Gene: |
TLR8 |
More about : TLR8 |
| Long gene name: |
toll like receptor 8 |
| Synonyms gene name: |
toll-like receptor 8 |
| Synonyms: |
CD288 |
| Locus: |
Xp22, 2 |
| Discovery year: |
2001-04-27 |
| GenBank acession: |
AF246971 |
| Entrez gene record: |
51311 |
| Pubmed identfication: |
11022119 |
| RefSeq identity: |
NM_016610 |
| Classification: |
CD molecules Toll like receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000021145 |
| Locus Specific Databases: |
Mental Retardation database |