| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Bim |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the Bim antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Bim antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O43521 |
| Purity: |
Purified |
| Description: |
BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities, BCL2L1/BCL-X(L), Bim contains a Bcl-2 homology domain 3 (BH3), It has been shown to interact with other members of the BCL-2 protein family, The expression of this gene can be induced by nerve growth factor (NGF), Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection, and MCL1, and to act as an apoptotic activator, as well as by the forkhead transcription factor FKHR-L1, including BCL2, which suggests a role of this gene in neuronal and lymphocyte apoptosis, Bim belongs to the BCL-2 protein family |
| Immunogen: |
A portion of amino acids 130-165 from the human protein was used as the immunogen for this Bim antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Bim antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Bim |
| Short name: |
Bim Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Bim (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
994 |
| Gene: |
BCL2L11 |
More about : BCL2L11 |
| Long gene name: |
BCL2 like 11 |
| Synonyms gene name: |
BCL2-like 11 (apoptosis facilitator) |
| Synonyms: |
BOD BimL BimEL BimS BIM |
| Locus: |
2q13 |
| Discovery year: |
1999-12-10 |
| GenBank acession: |
AF032458 |
| Entrez gene record: |
10018 |
| Pubmed identfication: |
9731710 9430630 |
| Classification: |
BCL2 homology region 3 (BH3) only |
| Havana BLAST/BLAT: |
OTTHUMG00000131256 |
| Locus Specific Databases: |
LRG_620 |