| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
BMPR1B |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the BMPR1B antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This BMPR1B antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O00238 |
| Purity: |
Antigen affinity |
| Description: |
BMPs are involved in endochondral bone formation and embryogenesis, Mutations in this gene have been associated with primary pulmonary hypertension, The ligands of this receptor are BMPs, These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD, Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding, which are members of the TGF-beta superfamily, This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases |
| Immunogen: |
A portion of amino acids 134-162 from the human protein was used as the immunogen for this BMPR1B antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the BMPR1B antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
BMPR1B |
| Short name: |
BMPR1B Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
classification IB (Antibody to), bone morphogenetic protein receptor |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ALK-6 and ALK6 and CDw293, BMPR1B and IDBG-30667 and ENSG00000138696 and 658, BMPR1B and IDBG-641011 and ENSBTAG00000002081 and 407128, Bmpr1b and IDBG-196928 and ENSMUSG00000052430 and 12167, Plasma membranes, this GO :0001501 and skeletal system development and biological process this GO :0001502 and cartilage condensation and biological process this GO :0001550 and ovarian cumulus expansion and biological process this GO :0001654 and eye development and biological process this GO :0002062 and chondrocyte differentiation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005025 and transforming growth factor beta receptor activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity and also this GO :0004702 : receptor signaling protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005024 : transforming growth factor beta-activated receptor activity and also this GO :0005025 : transforming growth factor beta receptor activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity, this GO :0004702 : receptor signaling protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005024 : transforming growth factor beta-activated receptor activity, this GO :0005025 : transforming growth factor beta receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0046332 : SMAD binding, this GO :0046872 : metal ion binding, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0046332 : SMAD binding and also this GO :0046872 : metal ion binding, transferring phosphorus-containing groups and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030154 and cell differentiation and biological process this GO :0030501 and positive regulation of bone mineralization and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0031290 and retinal ganglion cell axon guidance and biological process this GO :0035108 and limb morphogenesis and biological process this GO :0042698 and ovulation cycle and biological process this GO :0043010 and camera-type eye development and biological process this GO :0043235 and receptor complex and cellular component this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045669 and positive regulation of osteoblast differentiation and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0060041 and retina development in camera-type eye and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process, transforming growth factor beta receptor activity, type I, type I and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, type I and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006954 and inflammatory response and biological process this GO :0007178 and transmembrane receptor protein serine/threonine kinase signaling pathway and biological process this GO :0009953 and dorsal/ventral pattern formation and biological process this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, type IB, bone morphogenetic protein receptor |
| Identity: |
1077 |
| Gene: |
BMPR1B |
More about : BMPR1B |
| Long gene name: |
bone morphogenetic protein receptor type 1B |
| Synonyms gene name: |
bone morphogenetic protein receptor, type IB |
| Synonyms: |
ALK6 CDw293 |
| Locus: |
4q22, 3 |
| Discovery year: |
1997-03-19 |
| GenBank acession: |
D89675 |
| Entrez gene record: |
658 |
| Pubmed identfication: |
8140412 9730621 |
| RefSeq identity: |
NM_001203 |
| Classification: |
Type 1 receptor serine/threonine kinases CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000130991 |