| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
BMPR1B |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the BMPR1B antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This BMPR1B antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O00238 |
| Purity: |
Antigen affinity |
| Description: |
Astrom et al, BMPR1B was expressed at a significantly reduced level in cancerous prostate tissue, BMPs are involved in endochondral bone formation and embryogenesis, By analysis of a monochromosome hybrid mapping panel and by FISH, Ide et al, It is a member of the bone morphogenetic protein(BMP) receptor family of transmembrane serine/threonine kinases, The ligands of this receptor are BMPs, These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine(threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD, Type II receptors bind ligands in the absence of type I receptors, While BMPR1A and BMPR2 were expressed at similar levels in all prostate tissues, also known as ALK6, but they require their respective type I receptors for signaling, is a protein which in humans is encoded by the BMPR1B gene, whereas type I receptors require their respective type II receptors for ligand binding, which are members of the TGF-beta superfamily, (1997) compared BMP receptor expression in normal and cancerous prostate tissues, (1999) mapped the BMPR1B gene to chromosome 4q22-q24, Bone Morphogenetic Protein Receptor Type IB |
| Immunogen: |
An amino acid sequence from the middle region of human Bone Morphogenetic Protein Receptor Type IB (FCYFRYKRQETRPRYS) was used as the immunogen for this BMPR1B antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the BMPR1B antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
BMPR1B |
| Short name: |
BMPR1B Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
classification IB (Antibody to), bone morphogenetic protein receptor |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ALK-6 and ALK6 and CDw293, BMPR1B and IDBG-30667 and ENSG00000138696 and 658, BMPR1B and IDBG-641011 and ENSBTAG00000002081 and 407128, Bmpr1b and IDBG-196928 and ENSMUSG00000052430 and 12167, Plasma membranes, this GO :0001501 and skeletal system development and biological process this GO :0001502 and cartilage condensation and biological process this GO :0001550 and ovarian cumulus expansion and biological process this GO :0001654 and eye development and biological process this GO :0002062 and chondrocyte differentiation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005025 and transforming growth factor beta receptor activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity and also this GO :0004702 : receptor signaling protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005024 : transforming growth factor beta-activated receptor activity and also this GO :0005025 : transforming growth factor beta receptor activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity, this GO :0004702 : receptor signaling protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005024 : transforming growth factor beta-activated receptor activity, this GO :0005025 : transforming growth factor beta receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0046332 : SMAD binding, this GO :0046872 : metal ion binding, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0046332 : SMAD binding and also this GO :0046872 : metal ion binding, transferring phosphorus-containing groups and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030154 and cell differentiation and biological process this GO :0030501 and positive regulation of bone mineralization and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0031290 and retinal ganglion cell axon guidance and biological process this GO :0035108 and limb morphogenesis and biological process this GO :0042698 and ovulation cycle and biological process this GO :0043010 and camera-type eye development and biological process this GO :0043235 and receptor complex and cellular component this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045669 and positive regulation of osteoblast differentiation and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0060041 and retina development in camera-type eye and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process, transforming growth factor beta receptor activity, type I, type I and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, type I and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006954 and inflammatory response and biological process this GO :0007178 and transmembrane receptor protein serine/threonine kinase signaling pathway and biological process this GO :0009953 and dorsal/ventral pattern formation and biological process this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, type IB, bone morphogenetic protein receptor |
| Identity: |
1077 |
| Gene: |
BMPR1B |
More about : BMPR1B |
| Long gene name: |
bone morphogenetic protein receptor type 1B |
| Synonyms gene name: |
bone morphogenetic protein receptor, type IB |
| Synonyms: |
ALK6 CDw293 |
| Locus: |
4q22, 3 |
| Discovery year: |
1997-03-19 |
| GenBank acession: |
D89675 |
| Entrez gene record: |
658 |
| Pubmed identfication: |
8140412 9730621 |
| RefSeq identity: |
NM_001203 |
| Classification: |
Type 1 receptor serine/threonine kinases CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000130991 |