| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HDAC1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB, IF |
| Recommended dilutions: |
Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the HDAC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This HDAC1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13547 |
| Purity: |
Purified |
| Description: |
HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex, It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation, Together with metastasis-associated protein-2, catalyzed by multisubunit complexes, it deacetylates p53 and modulates its effect on cell growth and apoptosis, play a key role in the regulation of eukaryotic gene expression, Histone acetylation and deacetylation |
| Immunogen: |
A portion of amino acids 1-30 from the human protein was used as the immunogen for this HDAC1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the HDAC1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HDAC1 |
| Short name: |
HDAC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
histone deacetylase 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0006476 and protein deacetylation and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007596 and blood coagulation and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009913 and epidermal cell differentiation and biological process this GO :0010467 and gene expression and biological process this GO :0010870 and positive regulation of receptor biosynthetic process and biological process this GO :0016032 and viral process and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0016580 and Sin3 complex and cellular component this GO :0016581 and NuRD complex and cellular component this GO :0019213 and deacetylase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0031492 and nucleosomal DNA binding and molecular function this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0032922 and circadian regulation of gene expression and biological process this GO :0033558 and protein deacetylase activity and molecular function this GO :0033613 and activating transcription factor binding and molecular function this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042733 and embryonic digit morphogenesis and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0043044 and ATP-dependent chromatin remodeling and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043922 and negative regulation by host of viral transcription and biological process this GO :0045087 and innate immune response and biological process this GO :0045786 and negative regulation of cell cycle and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0060766 and negative regulation of androgen receptor signaling pathway and biological process this GO :0060789 and hair follicle placode formation and biological process this GO :0061029 and eyelid development in camera-type eye and biological process this GO :0061198 and fungiform papilla formation and biological process this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, HDAC1 and IDBG-644586 and ENSBTAG00000012698 and 404126, HDAC1 and IDBG-95712 and ENSG00000116478 and 3065, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0000790 and nuclear chromatin and cellular component this GO :0000976 and transcription regulatory region sequence-specific DNA binding and molecular function this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0000980 and RNA polymerase II distal enhancer sequence-specific DNA binding and molecular function this GO :0001047 and core promoter binding and molecular function this GO :0001103 and RNA polymerase II repressing transcription factor binding and molecular function this GO :0001106 and RNA polymerase II transcription corepressor activity and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006338 and chromatin remodeling and biological process this GO :0006351 and transcription, this GO :0000976 : transcription regulatory region sequence-specific DNA binding, this GO :0000976 : transcription regulatory region sequence-specific DNA binding and also this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0000980 : RNA polymerase II distal enhancer sequence-specific DNA binding and also this GO :0001047 : core promoter binding and also this GO :0001103 : RNA polymerase II repressing transcription factor binding and also this GO :0001106 : RNA polymerase II transcription corepressor activity and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0004407 : histone deacetylase activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0019213 : deacetylase activity and also this GO :0019899 : enzyme binding and also this GO :0031492 : nucleosomal DNA binding and also this GO :0032041 : NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033558 : protein deacetylase activity and also this GO :0033613 : activating transcription factor binding and also this GO :0042826 : histone deacetylase binding and also this GO :0046969 : NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970 : NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0097372 : NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000980 : RNA polymerase II distal enhancer sequence-specific DNA binding, this GO :0001047 : core promoter binding, this GO :0001103 : RNA polymerase II repressing transcription factor binding, this GO :0001106 : RNA polymerase II transcription corepressor activity, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0004407 : histone deacetylase activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0019213 : deacetylase activity, this GO :0019899 : enzyme binding, this GO :0031492 : nucleosomal DNA binding, this GO :0032041 : NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0033558 : protein deacetylase activity, this GO :0033613 : activating transcription factor binding, this GO :0042826 : histone deacetylase binding, this GO :0046969 : NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046970 : NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0097372 : NAD-dependent histone deacetylase activity (H3-K18 specific), this GO N-10 and HD1 and RPD3 and RPD3L1, histone deacetylase 1 |
| Identity: |
4852 |
| Gene: |
HDAC1 |
More about : HDAC1 |
| Long gene name: |
histone deacetylase 1 |
| Synonyms gene: |
RPD3L1 |
| Synonyms: |
HD1 GON-10 |
| Locus: |
1p35, 1 , 2-p35 |
| Discovery year: |
1996-11-15 |
| GenBank acession: |
D50405 |
| Entrez gene record: |
3065 |
| Pubmed identfication: |
8602529 |
| RefSeq identity: |
NM_004964 |
| Classification: |
NuRD complex Histone deacetylases, class I EMSY complex SIN3 histone deacetylase complex |
| Havana BLAST/BLAT: |
OTTHUMG00000007529 |