SREBP2 Antibody

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Catalog number: F40837-0.4ML
Price: 406 €
Supplier: NJS poly
Product name: SREBP2 Antibody
Quantity: 0.4 ml
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Category: Antibody
Concentration: pH 7, with 0, 09% sodium azide, 4, In 1X PBS
Form: Antigen affinity purified
Conjugation: Unconjugated
Clone: Polyclonal antibody
Recognised antigen: SREBP2
Host animal: Rabbit (Oryctolagus cuniculus)
Clonality: Polyclonal (rabbit origin)
Species reactivity: Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications: ELISA, IF, WB, IHC
Recommended dilutions: IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000
Notes: Titration of the SREBP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented use: This SREBP2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #: Q12772
Purity: Antigen affinity
Description: Each SREBP consists of three domains, SREBP-1c, SREBP-2 is ubiquitously detected in various tissues, SREBP-2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway, Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein, Upon cholesterol depletion, a middle hydrophobic region of ~80 amino acids containing two hydrophobic transmembrane segments, and SREBP-2, and a carboxy-terminal regulatory domain of ~590 amino acids, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism, including SREBP-1a, including an amino-terminal transcription factor domain of ~480 amino acids, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol, SREBPs
Immunogen: A portion of amino acids 399-427 from the human protein was used as the immunogen for this SREBP2 antibody
Storage: Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SREBP2 antibody and store frozen at -20 deg
Properties: C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene target: SREBP2
Short name: SREBP2 Antibody
Technique: antibodies against human proteins, antibodies for, Antibody
Alternative name: SREBP2 (Antibody to)
Alternative technique: antibodies
Identity: 11290
Gene: SREBF2 | More about : SREBF2
Long gene name: sterol regulatory element binding transcription factor 2
Synonyms: SREBP2 bHLHd2
Locus: 22q13, 2
Discovery year: 1994-11-23
GenBank acession: U02031
Entrez gene record: 6721
Pubmed identfication: 7903453
RefSeq identity: NM_004599
Classification: Basic helix-loop-helix proteins
Havana BLAST/BLAT: OTTHUMG00000151261

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