| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CCR8 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the CCR8 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This CCR8 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P51685 |
| Purity: |
Antigen affinity |
| Description: |
CCR8 is located at the chemokine receptor gene cluster region, Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites, I-309, More specifically, Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis, This receptor protein preferentially expresses in the thymus, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors, CCR8 encodes a member of the beta chemokine receptor family |
| Immunogen: |
A portion of amino acids 290-317 from the human protein was used as the immunogen for this CCR8 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the CCR8 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CCR8 |
| Short name: |
CCR8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
chemokine (C-C motif) receptor 8 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, C-C chemokine receptor activity, CC-CKR-8 and CCR-8 and CDw198 and CKRL1 and CMKBR8 and CMKBRL2 and CY6 and GPRCY6 and TER1, CCR8 and IDBG-26700 and ENSG00000179934 and 1237, Ccr8 and IDBG-205018 and ENSMUSG00000042262 and 12776, Plasma membranes, this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006935 and chemotaxis and biological process this GO :0006955 and immune response and biological process this GO :0007155 and cell adhesion and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0015026 and coreceptor activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016493 and C-C chemokine receptor activity and molecular function this GO :0070098 and chemokine-mediated signaling pathway and biological process, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0004950 : chemokine receptor activity and also this GO :0005515 : protein binding and also this GO :0015026 : coreceptor activity and also this GO :0016493 : C-C chemokine receptor activity, this GO :0004950 : chemokine receptor activity, this GO :0005515 : protein binding, this GO :0015026 : coreceptor activity, this GO :0016493 : C-C chemokine receptor activity, 30825 and IDBG-647797 and ENSBTAG00000015483 and 407772, chemokine (C-C motif) receptor 8 |
| Identity: |
1609 |
| Gene: |
CCR8 |
More about : CCR8 |
| Long gene name: |
C-C motif chemokine receptor 8 |
| Synonyms gene: |
CMKBRL2 CMKBR8 |
| Synonyms gene name: |
chemokine (C-C motif) receptor 8 |
| Synonyms: |
CY6 TER1 CKR-L1 GPR-CY6 CDw198 |
| Locus: |
3p22, 1 |
| Discovery year: |
1997-04-21 |
| GenBank acession: |
D49919 |
| Entrez gene record: |
1237 |
| Pubmed identfication: |
8816377 8886020 |
| RefSeq identity: |
NM_005201 |
| Classification: |
CD molecules C-C motif chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000131290 |