Dnmt3a Antibody

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Catalog number: F40603-0.4ML
Price: 406 €
Supplier: NJS poly
Product name: Dnmt3a Antibody
Quantity: 0.4 ml
Other quantities: 0.08 ml 199€ 0.1ml 263€ 0.4 ml 406€
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Category: Antibody
Concentration: pH 7, with 0, 09% sodium azide, 4, In 1X PBS
Form: Purified
Conjugation: Unconjugated
Clone: Polyclonal antibody
Recognised antigen: Dnmt3a
Host animal: Rabbit (Oryctolagus cuniculus)
Clonality: Polyclonal (rabbit origin)
Species reactivity: Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications: ELISA, IHC, WB
Recommended dilutions: IHC (Paraffin): 1:50-1:100, Western blot: 1:1000
Notes: Titration of the Dnmt3a antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented use: This Dnmt3a antibodyis to be used only for research purposes and not for diagnostics
Uniprot #: Q9Y6K1
Purity: Purified
Description: Acts as a transcriptional corepressor for ZBTB18, Can actively repress transcription through the recruitment of HDAC activity, DNA methylation is coordinated with methylation of histones, It modifies DNA in a non-processive manner and also methylates non-CpG sites, May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1, Plays a role in paternal and maternal imprinting, Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites, Required for methylation of most imprinted loci in germ cells, [UniProt], Dnmt3a is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development
Immunogen: A portion of amino acids 457-486 from the human protein was used as the immunogen for this Dnmt3a antibody
Storage: Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Dnmt3a antibody and store frozen at -20 deg
Properties: C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene target: Dnmt3a
Short name: Dnmt3a Antibody
Technique: antibodies against human proteins, antibodies for, Antibody
Alternative name: Dnmt3a (Antibody to)
Alternative technique: antibodies
Identity: 2978
Gene: DNMT3A | More about : DNMT3A
Long gene name: DNA methyltransferase 3 alpha
Synonyms gene name: DNA (cytosine-5-)-methyltransferase 3 alpha
Locus: 2p23, 3
Discovery year: 1998-07-15
Entrez gene record: 1788
Pubmed identfication: 9662389 10433969
RefSeq identity: NM_022552
Classification: PWWP domain containing
Havana BLAST/BLAT: OTTHUMG00000094777
Locus Specific Databases: LRG_459

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