| Long name: |
Dnmt3a Primary Polyclonal Antibody |
| Also known as: |
Dnmt3a PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Dnmt3a |
| Specificity: |
This is a highly specific antibody against Dnmt3a |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Dnmt3a |
| Gene ID number: |
1788 |
| Swiss Prot: |
Q9Y6K1 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a transcriptional corepressor for ZBTB18, Can actively repress transcription through the recruitment of HDAC activity, DNA methylation is coordinated with methylation of histones, It modifies DNA in a non-processive manner and also methylates non-CpG sites, May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1, Plays a role in paternal and maternal imprinting, Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites, Required for methylation of most imprinted loci in germ cells, Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DNA (cytosine-5)-methyltransferase 3A, DNA MTase HsaIIIA, DNA methyltransferase HsaIIIA, DNMT3A2, Dnmt3a, M, HsaIIIA, TBRS |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Dnmt3a |
| Short name: |
Dnmt3a Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Dnmt3a (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2978 |
| Gene: |
DNMT3A |
More about : DNMT3A |
| Long gene name: |
DNA methyltransferase 3 alpha |
| Synonyms gene name: |
DNA (cytosine-5-)-methyltransferase 3 alpha |
| Locus: |
2p23, 3 |
| Discovery year: |
1998-07-15 |
| Entrez gene record: |
1788 |
| Pubmed identfication: |
9662389 10433969 |
| RefSeq identity: |
NM_022552 |
| Classification: |
PWWP domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000094777 |
| Locus Specific Databases: |
LRG_459 |