| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
KEAP1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the KEAP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This KEAP1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q14145 |
| Purity: |
Antigen affinity |
| Description: |
Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol, Targets PGAM5 for ubiquitination and degradation by the proteasome [UniProt], thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression, KEAP1 acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome |
| Immunogen: |
A portion of amino acids 422-449 from the human protein was used as the immunogen for this KEAP1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot the KEAP1 antibody and store frozen at -20 deg, Store at 4oC for up to one month |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
KEAP1 |
| Short name: |
KEAP1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
KEAP1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
23177 |
| Gene: |
KEAP1 |
More about : KEAP1 |
| Long gene name: |
kelch like ECH associated protein 1 |
| Synonyms: |
KIAA0132 MGC10630 MGC1114 MGC20887 MGC4407 MGC9454 INrf2 KLHL19 |
| Synonyms name: |
kelch-like family member 19 |
| Locus: |
19p13, 2 |
| Discovery year: |
2003-09-30 |
| GenBank acession: |
AF361886 |
| Entrez gene record: |
9817 |
| RefSeq identity: |
NM_012289 |
| Classification: |
BTB domain containing Kelch like |
| Havana BLAST/BLAT: |
OTTHUMG00000180579 |