| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
KEAP1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the KEAP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This KEAP1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q14145 |
| Purity: |
Antigen affinity |
| Description: |
Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, In the presence of the electrophilic agent diethylmalate, It has been shown to interact with Nrf2, KEAP1 has become a very attractive drug target, Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat(DGR), Nrf2 activity is released from KEAP1 and Nrf2 translocate to the nucleus, Nrf2 is anchored in the cytoplasm through binding to Keap1, Under quiescent conditions, a master regulator of the antioxidant response, and Keap1 represses Nrf2 activation, facilitates the ubiquitination and subsequent proteolysis of Nrf2, in turn, module, or Kelch, which, which is important for the amelioration of oxidative stress, KEAP1 (Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene |
| Immunogen: |
Amino acids 46-60 (QHGNRTFSYTLEDHT-human) were used as the immunogen for this KEAP1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the KEAP1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
KEAP1 |
| Short name: |
KEAP1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
KEAP1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
23177 |
| Gene: |
KEAP1 |
More about : KEAP1 |
| Long gene name: |
kelch like ECH associated protein 1 |
| Synonyms: |
KIAA0132 MGC10630 MGC1114 MGC20887 MGC4407 MGC9454 INrf2 KLHL19 |
| Synonyms name: |
kelch-like family member 19 |
| Locus: |
19p13, 2 |
| Discovery year: |
2003-09-30 |
| GenBank acession: |
AF361886 |
| Entrez gene record: |
9817 |
| RefSeq identity: |
NM_012289 |
| Classification: |
BTB domain containing Kelch like |
| Havana BLAST/BLAT: |
OTTHUMG00000180579 |