| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
GNAS |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IF, IHC, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the GNAS antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This GNAS antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q5FWY2 |
| Purity: |
Antigen affinity |
| Description: |
Albright hereditary osteodystrophy, Alternative splicing of downstream exons of the GNAS gene is observed, McCune-Albright syndrome, Multiple transcript variants have been found for this gene, Mutations in this gene result in pseudohypoparathyroidism type 1a, The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses, and some pituitary tumors, but the full-length nature and/or biological validity of some variants have not been determined, polyostotic fibrous dysplasia of bone, progressive osseus heteroplasia, pseudohypoparathyroidism type 1b, pseudopseudohypoparathyroidism, which results in different forms of the stimulatory G protein alpha subunit, Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems |
| Immunogen: |
A portion of amino acids 287-315 from the human protein was used as the immunogen for this GNAS antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the GNAS antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
GNAS |
| Short name: |
GNAS Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
GNAS (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4392 |
| Gene: |
GNAS |
More about : GNAS |
| Long gene name: |
GNAS complex locus |
| Synonyms gene: |
GNAS1 |
| Synonyms gene name: |
alpha stimulating activity polypeptide 1 , guanine nucleotide binding protein (G protein) |
| Synonyms: |
NESP55 NESP GNASXL GPSA SCG6 SgVI |
| Synonyms name: |
secretogranin VI G protein subunit alpha S |
| Locus: |
20q13, 32 |
| Discovery year: |
1990-06-29 |
| GenBank acession: |
M21142 |
| Entrez gene record: |
2778 |
| RefSeq identity: |
NM_000516 |
| Classification: |
Granins |
| Havana BLAST/BLAT: |
OTTHUMG00000033069 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database |