| Long name: |
1, 3) Monoclonal Antibody, GNAS (559CT 16 |
| Also known as: |
1, 3) Monoclonal Antibody, GNAS (559CT 16 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
GNAS |
| Specificity: |
This is a highly specific antibody against GNAS |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1, 3, 559CT 16 |
| Source: |
This GNAS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from human GNAS |
| Swiss Prot: |
Q5FWY2 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:300) |
| Cross reactivity: |
Mouse |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Albright hereditary osteodystrophy, Alternative splicing of downstream exons of the GNAS gene is observed, McCune-Albright syndrome, Multiple transcript variants have been found for this gene, Mutations in this gene result in pseudohypoparathyroidism type 1a, The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses, and some pituitary tumors, but the full-length nature and/or biological validity of some variants have not been determined, polyostotic fibrous dysplasia of bone, progressive osseus heteroplasia, pseudohypoparathyroidism type 1b, pseudopseudohypoparathyroidism, which results in different forms of the stimulatory G protein alpha subunit, Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems |
| Purification method: |
09% (W/V) sodium azide, Mouse monoclonal antibody supplied in crude ascites with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
1, 3) Monoclonal, GNAS (559CT 16 |
| Short name: |
1, 3) Monoclonal Antibody, GNAS (559CT 16 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
1, 3) monoclonal (Antibody to), GNAS (559CT 16 |
| Alternative technique: |
antibodies |
| Identity: |
4392 |
| Gene: |
GNAS |
More about : GNAS |
| Long gene name: |
GNAS complex locus |
| Synonyms gene: |
GNAS1 |
| Synonyms gene name: |
alpha stimulating activity polypeptide 1 , guanine nucleotide binding protein (G protein) |
| Synonyms: |
NESP55 NESP GNASXL GPSA SCG6 SgVI |
| Synonyms name: |
secretogranin VI G protein subunit alpha S |
| Locus: |
20q13, 32 |
| Discovery year: |
1990-06-29 |
| GenBank acession: |
M21142 |
| Entrez gene record: |
2778 |
| RefSeq identity: |
NM_000516 |
| Classification: |
Granins |
| Havana BLAST/BLAT: |
OTTHUMG00000033069 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database |