| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FEZ1 |
| Specificity: |
This antibody reacts specifically with FEZ1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human FEZ1 |
| Gene ID: |
9638 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
During cell-cycle progression, FEZ1 acts as a negative regulator of cell growth, FEZ1 is expressed in normal breast and prostate, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase, The 8p22-p21 region contains the FEZ1 gene, The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif, The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors, This absence of FEZ1 may be due to several factors, but alterations in FEZ1 expression result in abnormal cell growth, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region, prostate and breast, which is altered in tumors of the esophagus, Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
UNC-76 |
| Also known as: |
FEZ1 Polyclonal Antibody |
| Other name: |
Anti-FEZ1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FEZ1 |
| Short name: |
Anti-FEZ1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-fasciculation and elongation protein zeta 1 (zygin I) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
FEZ1 and IDBG-642679 and ENSBTAG00000009124 and 511751, FEZ1 and IDBG-75464 and ENSG00000149557 and 9638, Fez1 and IDBG-149600 and ENSMUSG00000032118 and 235180, Plasma membranes, protein N-terminus binding, this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005813 and centrosome and cellular component this GO :0005874 and microtubule and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006810 and transport and biological process this GO :0007155 and cell adhesion and biological process this GO :0007399 and nervous system development and biological process this GO :0007411 and axon guidance and biological process this GO :0010976 and positive regulation of neuron projection development and biological process this GO :0015630 and microtubule cytoskeleton and cellular component this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0042995 and cell projection and cellular component this GO :0043015 and gamma-tubulin binding and molecular function this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0047485 and protein N-terminus binding and molecular function this GO :0051654 and establishment of mitochondrion localization and biological process this GO :0071363 and cellular response to growth factor stimulus and biological process, this GO :0005080 : protein kinase C binding, this GO :0005080 : protein kinase C binding and also this GO :0005515 : protein binding and also this GO :0043015 : gamma-tubulin binding and also this GO :0047485 : protein N-terminus binding, this GO :0005515 : protein binding, this GO :0043015 : gamma-tubulin binding, this GO :0047485 : protein N-terminus binding, fasciculation and elongation protein zeta 1 (zygin I) |
| Identity: |
3659 |
| Gene: |
FEZ1 |
More about : FEZ1 |
| Long gene name: |
fasciculation and elongation protein zeta 1 |
| Synonyms name: |
zygin I |
| Locus: |
11q24, 2 |
| Discovery year: |
1999-12-14 |
| GenBank acession: |
U60060 |
| Entrez gene record: |
9638 |
| Pubmed identfication: |
9096408 15843383 |
| RefSeq identity: |
NM_005103 |
| Havana BLAST/BLAT: |
OTTHUMG00000165886 |