| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
AICDA |
| Specificity: |
This antibody reacts specifically with AICDA |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human AICDA |
| Gene ID: |
57379 |
| Swiss Prot: |
Q9GZX7 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Involved in somatic hypermutation, May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation, Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses, and class-switch recombination in B-lymphocytes, gene conversion, Single-stranded DNA-specific cytidine deaminase |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HIGM2 CDA2 ARP2 AID |
| Also known as: |
AICDA Polyclonal Antibody |
| Other name: |
Anti-AICDA Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
AICDA |
| Short name: |
Anti-AICDA (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-activation-induced cytidine deaminase (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
AICDA and IDBG-17253 and ENSG00000111732 and 57379, Aicda and IDBG-185563 and ENSMUSG00000040627 and 11628, BT, acting on carbon-nitrogen (but not peptide) bonds, acting on carbon-nitrogen (but not peptide) bonds, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, in cyclic amidines, in cyclic amidines, in cyclic amidines and molecular function this GO :0030183 and B cell differentiation and biological process this GO :0045087 and innate immune response and biological process this GO :0045190 and isotype switching and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0080111 and DNA demethylation and biological process this GO :0090310 and negative regulation of methylation-dependent chromatin silencing and biological process, nuclei, this GO :0000178 and exosome (RNase complex) and cellular component this GO :0003824 and catalytic activity and molecular function this GO :0004126 and cytidine deaminase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006397 and mRNA processing and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0009972 and cytidine deamination and biological process this GO :0016445 and somatic diversification of immunoglobulins and biological process this GO :0016446 and somatic hypermutation of immunoglobulin genes and biological process this GO :0016814 and hydrolase activity, this GO :0003824 : catalytic activity, this GO :0003824 : catalytic activity and also this GO :0004126 : cytidine deaminase activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016814 : hydrolase activity, this GO :0004126 : cytidine deaminase activity, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0016814 : hydrolase activity, 56893 and IDBG-639763 and ENSBTAG00000018849 and 539888, activation-induced cytidine deaminase |
| Identity: |
13203 |
| Gene: |
AICDA |
More about : AICDA |
| Long gene name: |
activation induced cytidine deaminase |
| Synonyms gene name: |
activation-induced cytidine deaminase |
| Locus: |
12p13, 31 |
| Discovery year: |
2000-09-19 |
| GenBank acession: |
AB040430 |
| Entrez gene record: |
57379 |
| RefSeq identity: |
NM_020661 |
| Classification: |
Apolipoprotein B mRNA editing enzyme catalytic subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000168676 |
| Locus Specific Databases: |
AICDA base: Mutation registry for Aid deficiency LRG_17 |