| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ETHE1 |
| Specificity: |
This antibody reacts specifically with ETHE1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human E1 |
| Gene ID: |
23474 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
EE is an autosomal recessive disorder characterized by neurodevelopmental delay and regression, It is also associated with persistent lactic acidemia and ethylmalonic and methylsuccinic aciduria, May function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm, Suppresses p53-induced apoptosis by preventing nuclear localization of RELA, acrocyanosis, diarrhea, leading to death in the first decade of life, recurrent petechiae, Involvement in disease:Defects in ETHE1 are a cause of ethylmalonic encephalopathy (EE) , Probably plays an important role in metabolic homeostasis in mitochondria |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
YF13H12 HSCO |
| Also known as: |
ETHE1 Polyclonal Antibody |
| Other name: |
Anti-ETHE1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ETHE1 |
| Short name: |
Anti-ETHE1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-ETHE1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
23287 |
| Gene: |
ETHE1 |
More about : ETHE1 |
| Long gene name: |
ETHE1, persulfide dioxygenase |
| Synonyms gene name: |
ethylmalonic encephalopathy 1 |
| Locus: |
19q13, 31 |
| Discovery year: |
2003-12-15 |
| Entrez gene record: |
23474 |
| Pubmed identfication: |
19136963 |
| RefSeq identity: |
NM_014297 |
| Havana BLAST/BLAT: |
OTTHUMG00000182697 |