| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SERPINA12 |
| Specificity: |
This antibody reacts specifically with SERPINA12 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SERPINA12/Vaspin |
| Gene ID: |
145264 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A number of such serpins have been shown to target cysteine proteases, It may modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues, Most inhibitory serpins target chymotrypsin-like serine proteases, Most serpins control proteolytic cascades, SerpinA12, SerpinA12 / Vaspin is expressed in visceral adipose tissues, SerpinA12 / Vaspin may be the compensatory molecule in the pathogenesis of metabolic syndrome and SerpinA12 / Vaspin recombinant protein or vaspin-mimicking agents such as vaspin analogs, Some serpins inhibit other classes of protease, These enzymes are defined by the presence of a nucleophilic serine residue in their catalytic site, These enzymes differ from serine proteases in that they are defined by the presence of a nucleophilic cysteine residue, Vaspin, Visceral adipose tissue-derived serine protease inhibitor, Visceral adipose-specific serpin and SERPINA12, also known as OL-64, but instead perform diverse functions such as storage (ovalbumin, certain serpins do not inhibit enzymes, cortisol-binding globulin) and tumor suppressor genes (maspin), hormone carriage proteins (thyroxine-binding globulin, in egg white), in their catalytic site, is a secreted protein which belongs to the serpin family, or small molecule agents may be the link to drug discovery and development, rather than a serine residue, May modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues, Serpins are the largest and most diverse family of protease inhibitors |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
OL-64 Vaspin |
| Also known as: |
SERPINA12 Polyclonal Antibody |
| Other name: |
Anti-SERPINA12 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SERPINA12 |
| Short name: |
Anti-SERPINA12 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SERPINA12 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
18359 |
| Gene: |
SERPINA12 |
More about : SERPINA12 |
| Long gene name: |
serpin family A member 12 |
| Synonyms gene name: |
antitrypsin), antitrypsin), clade A (alpha-1 antiproteinase, clade A (alpha-1 antiproteinase, member 12 , member 12 serpin peptidase inhibitor, serine (or cysteine) proteinase inhibitor |
| Locus: |
14q32, 13 |
| Discovery year: |
2004-05-21 |
| GenBank acession: |
AY177692 |
| Entrez gene record: |
145264 |
| Pubmed identfication: |
24172014 |
| RefSeq identity: |
NM_173850 |
| Classification: |
Serpin peptidase inhibitors |
| Havana BLAST/BLAT: |
OTTHUMG00000171349 |