| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MRC2 |
| Specificity: |
This antibody reacts specifically with MRC2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MRC2/CD280 |
| Gene ID: |
9902 |
| Swiss Prot: |
Q9UBG0 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis, May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, May contribute to cellular uptake, May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs), May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover, and thus may regulate protease activity at the cell surface, remodeling and degradation of extracellular collagen matrices, May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA0709 ENDO180 CLEC13E CD280 |
| Also known as: |
MRC2 Polyclonal Antibody |
| Other name: |
Anti-MRC2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MRC2 |
| Short name: |
Anti-MRC2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, C type 2 (polyclonal), antibody to-mannose receptor |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
C type 2, CD280 and CLEC13E and ENDO180 and UPARAP, MRC2 and IDBG-63031 and ENSG00000011028 and 9902, MRC2 and IDBG-641433 and ENSBTAG00000015739 and 529049, Mrc2 and IDBG-213230 and ENSMUSG00000020695 and 17534, Plasma membranes, carbohydrate binding, this GO :0001649 and osteoblast differentiation and biological process this GO :0005515 and protein binding and molecular function this GO :0005518 and collagen binding and molecular function this GO :0006897 and endocytosis and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0030246 and carbohydrate binding and molecular function this GO :0030574 and collagen catabolic process and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0005518 : collagen binding and also this GO :0030246 : carbohydrate binding, this GO :0005518 : collagen binding, this GO :0030246 : carbohydrate binding, mannose receptor |
| Identity: |
16875 |
| Gene: |
MRC2 |
More about : MRC2 |
| Long gene name: |
mannose receptor C type 2 |
| Synonyms gene name: |
C type 2 , mannose receptor |
| Synonyms name: |
C-type lectin domain family 13 member E endocytic receptor 180 |
| Locus: |
17q23 |
| Discovery year: |
2002-09-24 |
| GenBank acession: |
AB014609 |
| Entrez gene record: |
9902 |
| Pubmed identfication: |
9734811 8702911 |
| Classification: |
CD molecules C-type lectin domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000179178 |