| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
WAVE 1 |
| Specificity: |
This antibody reacts specifically with WAVE 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human WAVE 1 |
| Gene ID: |
8936 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating Actin reorganization downstream of the Rho family of small GTPases, The protein homologs WAVE1 and WAVE2 regulate membrane ruffling by inducing the formation of Actin filament clusters in response to GTP binding and by activating Rac, They mediate Actin polymerization by cooperating with the Arp2/3 complex, WAVE1, WAVE3 forms a multiprotein complex that links receptor kinases with Actin and plays a role in the transduction of signals involving changes in cell shape, function or motility, is expressed primarily in the brain, thereby promoting the formation of Actin filaments, which accumulate at focal adhesions and are also involved in the regulation of the Actin cytoskeleton, which is also designated SCAR (suppressor of cAR), while WAVE2 is widely expressed, with the expression highest in peripheral blood leukocytes, WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in Actin polymerization and cytoskeletal organization |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
WAVE1 SCAR1 KIAA0269 WAVE |
| Also known as: |
WAVE 1 Polyclonal Antibody |
| Other name: |
Anti-WAVE 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
WAVE 1 |
| Short name: |
Anti-WAVE 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-WAVE 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
12732 |
| Gene: |
WASF1 |
More about : WASF1 |
| Long gene name: |
WAS protein family member 1 |
| Synonyms gene name: |
WAS protein family, member 1 |
| Locus: |
6q21 |
| Discovery year: |
1999-09-21 |
| GenBank acession: |
D87459 |
| Entrez gene record: |
8936 |
| Pubmed identfication: |
9843499 9889097 |
| RefSeq identity: |
NM_003931 |
| Classification: |
A-kinase anchoring proteins Wiskott-Aldrich Syndrome protein family |
| Havana BLAST/BLAT: |
OTTHUMG00000015357 |