| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ADAMTS13 |
| Specificity: |
This antibody reacts specifically with ADAMTS13 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ADAMTS13 |
| Gene ID: |
11093 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura, Alternative splicing of this gene generates multiple transcript variants encoding different isoforms, Individual members of this family differ in the number of C-terminal TS motifs, Members of the family share several distinct protein modules, Nov 2008], The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, [provided by RefSeq, a disintegrin-like domain, a metalloproteinase domain, and a thrombospondin type 1 (TS) motif, and some have unique C-terminal domains, including a propeptide region, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule, This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
VWFCP TTP vWF-CP FLJ42993 MGC118899 MGC118900 DKFZp434C2322 |
| Also known as: |
ADAMTS13 Polyclonal Antibody |
| Other name: |
Anti-ADAMTS13 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ADAMTS13 |
| Short name: |
Anti-ADAMTS13 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
13 (polyclonal), ALEXA Fluor 594, antibody to-ADAM metallopeptidase including thrombospondin classification 1 motif |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
13, ADAM-TS13 and ADAMTS-13 and C9orf8 and vWF-CP and VWFCP, ADAMTS13 and IDBG-640733 and ENSBTAG00000015093 and, ADAMTS13 and IDBG-91330 and ENSG00000160323 and 11093, Adamts13 and IDBG-150457 and ENSMUSG00000014852 and 279028, Extracellular, this GO :0004175 and endopeptidase activity and molecular function this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005615 and extracellular space and cellular component this GO :0006508 and proteolysis and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0008233 and peptidase activity and molecular function this GO :0008237 and metallopeptidase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0009100 and glycoprotein metabolic process and biological process this GO :0009636 and response to toxic substance and biological process this GO :0009986 and cell surface and cellular component this GO :0016485 and protein processing and biological process this GO :0030168 and platelet activation and biological process this GO :0031012 and extracellular matrix and cellular component this GO :0034341 and response to interferon-gamma and biological process this GO :0034612 and response to tumor necrosis factor and biological process this GO :0043171 and peptide catabolic process and biological process this GO :0070670 and response to interleukin-4 and biological process, this GO :0004175 : endopeptidase activity, this GO :0004175 : endopeptidase activity and also this GO :0004222 : metalloendopeptidase activity and also this GO :0005178 : integrin binding and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0008233 : peptidase activity and also this GO :0008237 : metallopeptidase activity and also this GO :0008270 : zinc ion binding, this GO :0004222 : metalloendopeptidase activity, this GO :0005178 : integrin binding, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0008233 : peptidase activity, this GO :0008237 : metallopeptidase activity, this GO :0008270 : zinc ion binding, zinc ion binding, ADAM metallopeptidase with thrombospondin type 1 motif |
| Identity: |
1366 |
| Gene: |
ADAMTS13 |
More about : ADAMTS13 |
| Long gene name: |
ADAM metallopeptidase with thrombospondin type 1 motif 13 |
| Synonyms gene: |
C9orf8 |
| Synonyms gene name: |
13 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif |
| Locus: |
9q34, 2 |
| Discovery year: |
1999-08-23 |
| GenBank acession: |
AJ011374 |
| Entrez gene record: |
11093 |
| Pubmed identfication: |
11557746 11535495 |
| RefSeq identity: |
NM_139025 |
| Classification: |
ADAM metallopeptidases with thrombospondin type 1 motif |
| Havana BLAST/BLAT: |
OTTHUMG00000020876 |
| Locus Specific Databases: |
LRG_544 |