| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PCDHB11 |
| Specificity: |
This antibody reacts specifically with PCDHB11 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PCDHB11 |
| Gene ID: |
56125 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
PCDHB11 clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters, The beta cluster contains 16 genes and 3 pseudogenes, The extracellular domains interact in a homophilic manner to specify differential cell-cell connections, Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections, These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins, Unlike the alpha and gamma clusters, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily, not sharing common 3' exons as expected, one of three related gene clusters tandemly linked on chromosome five, the transcripts from these genes are made up of only one large exon, PCDHB11 is a member of the protocadherin beta gene cluster |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PCDH-BETA11 ME2 |
| Also known as: |
PCDHB11 Polyclonal Antibody |
| Other name: |
Anti-PCDHB11 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PCDHB11 |
| Short name: |
Anti-PCDHB11 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-protocadherin b 11 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
PCDHB11 and IDBG-50113 and ENSG00000197479 and 56125, Plasma membranes, calcium ion binding, this GO :0005509 and calcium ion binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007156 and homophilic cell adhesion and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007399 and nervous system development and biological process this GO :0007416 and synapse assembly and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016339 and calcium-dependent cell-cell adhesion and biological process, this GO :0005509 : calcium ion binding, this GO :0005509 : calcium ion binding, protocadherin beta 11 |
| Identity: |
8682 |
| Gene: |
PCDHB11 |
More about : PCDHB11 |
| Long gene name: |
protocadherin beta 11 |
| Synonyms name: |
cadherin ME2 |
| Locus: |
5q31, 3 |
| Discovery year: |
2000-06-28 |
| GenBank acession: |
AF152490 |
| Entrez gene record: |
56125 |
| Pubmed identfication: |
10380929 |
| RefSeq identity: |
NM_018931 |
| Classification: |
Clustered protocadherins |
| Havana BLAST/BLAT: |
OTTHUMG00000129618 |